Adiponectin Concentrations: A Genome-wide Association Study
- Authors
- Jee, Sun Ha; Sull, Jae Woong; Lee, Jong-Eun; Shin, Chol; Park, Jongkeun; Kimm, Heejin; Cho, Eun-Young; Shin, Eun-Soon; Yun, Ji Eun; Park, Ji Wan; Kim, Sang Yeun; Lee, Sun Ju; Jee, Eun Jung; Baik, Inkyung; Kao, Linda; Yoon, Sungjoo Kim; Jang, Yangsoo; Beaty, Terri H.
- Issue Date
- 8-10월-2010
- Publisher
- CELL PRESS
- Citation
- AMERICAN JOURNAL OF HUMAN GENETICS, v.87, no.4, pp.545 - 552
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF HUMAN GENETICS
- Volume
- 87
- Number
- 4
- Start Page
- 545
- End Page
- 552
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115525
- DOI
- 10.1016/j.ajhg.2010.09.004
- ISSN
- 0002-9297
- Abstract
- Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage) Another 2,304 subjects were used for follow-up replication studies with selected markers In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1 69 x 10(-15) in the initial sample, p = 6.58 x 10(-39) in the second genome-wide sample, and p = 2.12 x 10(-32) in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2 82 x 10(-83) The association of rs3865188 with high-molecular-weight adiponectm (p = 7.36 x 10(-58)) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold This study clearly shows that genetic variants in CDH13 Influence adiponectm levels in Korean adults.
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