Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun-Sun | - |
dc.contributor.author | Koo, Yoon-Chang | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Kim, Kyung-Yong | - |
dc.contributor.author | Lee, Kwang-Won | - |
dc.date.accessioned | 2021-09-07T23:37:35Z | - |
dc.date.available | 2021-09-07T23:37:35Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-10-05 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115531 | - |
dc.description.abstract | Aim of the study: The aqueous extract of Terminalia chebular fruits was reported to have anti-hyperglycemia and anti-diabetic complication effects. The present study therefore investigated the protective mechanism of chebulic acid, a phenolcarboxylic acid compound isolated from the ripe fruits of Terminalia chebula against advanced glycation endproducts (AGEs)-induced endothelial cell dysfunction. Materials and methods: To investigate the protective mechanism of chebulic acid against vascular endothelial dysfunction human umbilical vein endothelial cells (HUVEC) were treated with chebulic acid in the presence/absence of glyceraldehyde-related AGEs (glycer-AGEs). Results: HUVEC incubated with 100 mu g/ml of glycer-AGEs had significantly enhanced reactive oxygen species formation, whereas the treatment of chebulic acid dose-dependently reduced glycer-AGE-induced formation to 108.2 +/- 1.9% for 25 mu M versus 137.8 +/- 1.1% for glycer-AGEs treated alone. The transendothelial electrical resistance (TER) value of the glycer-AGEs group was dramatically decreased to 76.9 +/- 2.2% compared to the control, whereas chebulic acid treatment prevented glycer-AGE-induced TER change with a value of 91.3 +/- 5.3%. The incubation of confluent HUVEC with 100 mu g/ml of glycer-AGEs for 24 h remarkably increased the adhesion of human monocytic THP-1 cells compared to non-stimulated HUVEC. These increases in HUVEC adhesiveness were dose-dependently reduced by chebulic acid. Conclusions: The present study shows the effects of chebulic acid against the progression of AGE-induced endothelial cell dysfunction suggesting that this compound may constitute a promising intervention agent against diabetic vascular complications. (C) 2010 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | GROWTH-FACTOR | - |
dc.subject | END-PRODUCTS | - |
dc.subject | HYPERGLYCEMIA | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | GLUCOSE | - |
dc.subject | PROTEIN | - |
dc.subject | STRESS | - |
dc.subject | RETZ. | - |
dc.subject | MECHANISMS | - |
dc.subject | EXPRESSION | - |
dc.title | Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun-Sun | - |
dc.contributor.affiliatedAuthor | Suh, Hyung Joo | - |
dc.contributor.affiliatedAuthor | Lee, Kwang-Won | - |
dc.identifier.doi | 10.1016/j.jep.2010.07.039 | - |
dc.identifier.scopusid | 2-s2.0-77956647697 | - |
dc.identifier.wosid | 000283411400008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ETHNOPHARMACOLOGY, v.131, no.3, pp.567 - 574 | - |
dc.relation.isPartOf | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.title | JOURNAL OF ETHNOPHARMACOLOGY | - |
dc.citation.volume | 131 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 567 | - |
dc.citation.endPage | 574 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | END-PRODUCTS | - |
dc.subject.keywordPlus | HYPERGLYCEMIA | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | RETZ. | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Terminaila chebula | - |
dc.subject.keywordAuthor | Chebulic acid | - |
dc.subject.keywordAuthor | Diabetic complications | - |
dc.subject.keywordAuthor | Advanced glycation end products | - |
dc.subject.keywordAuthor | Endothelial dysfunction | - |
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