Outcomes of follow-up CT for small (5-10-mm) arterially enhancing nodules in the liver and risk factors for developing hepatocellular carcinoma in a surveillance population
- Authors
- Park, Min Jung; Kim, Young-Sun; Lee, Won Jae; Lim, Hyo K.; Rhim, Hyunchul; Lee, Jongmee
- Issue Date
- 10월-2010
- Publisher
- SPRINGER
- Keywords
- Hepatocellular carcinoma; Computed tomography; Hepatocarcinogenesis; Chronic liver disease
- Citation
- EUROPEAN RADIOLOGY, v.20, no.10, pp.2397 - 2404
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN RADIOLOGY
- Volume
- 20
- Number
- 10
- Start Page
- 2397
- End Page
- 2404
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115573
- DOI
- 10.1007/s00330-010-1810-y
- ISSN
- 0938-7994
- Abstract
- To evaluate the outcomes of small (5-10 mm), arterially enhancing nodules (SAENs) shown exclusively at the hepatic arterial phase of CT in a hepatocellular carcinoma (HCC) surveillance population and to determine risk factors for developing HCC. The study population included 112 patients (male:female = 100:12; aged 36-92 years) with 175 SAENs who were at risk of HCC. We evaluated serial changes during follow-up (1.4-41.8 months, mean 35.7 months) and analysed the initial CT findings of SAENs and the accompanying lesions to elucidate the risk factors for HCC development. Of 175 SAENs, 101(57.7%) disappeared and 34(19.4%) persisted. Forty SAENs (22.9%) became HCC in 33 patients (29.5%). Presence of HCC treatment history (p = 0.005, risk ratio = 7.429), a larger size of SAEN (p = 0.003, risk ratio = 1.630), presence of coexistent HCC (p = 0.021, risk ratio = 3.777) and absence of coexistent typical arterioportal shunts (p = 0.003, risk ratio = 4.459) turned out to be independently significant risk factors for future development of HCC. SAENs were frequently seen in an HCC surveillance population and have a 22.9% probability of becoming HCC on a per-lesion basis. Risk increased particularly when the lesion was associated with a previous or concurrent HCC, a large size or found without a coexistent typical arterioportal shunt.
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