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Cloning and characterization of microRNAs from porcine skeletal muscle and adipose tissue

Authors
Kim, JungSeo, Hye YounLim, Do HwanHong, Jae SangPark, Young HeePark, Dae CheulHong, Ki-ChangWhang, Kwang YounLee, Young Sik
Issue Date
Oct-2010
Publisher
SPRINGER
Keywords
MicroRNA; Skeletal muscle; Adipose tissue; Pig
Citation
MOLECULAR BIOLOGY REPORTS, v.37, no.7, pp.3567 - 3574
Indexed
SCIE
SCOPUS
Journal Title
MOLECULAR BIOLOGY REPORTS
Volume
37
Number
7
Start Page
3567
End Page
3574
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115598
DOI
10.1007/s11033-010-0005-6
ISSN
0301-4851
Abstract
MicroRNAs (miRNAs) are an abundant class of small regulatory RNAs that regulate the stability and translation of cognate mRNAs. Although an increasing number of porcine miRNAs has recently been identified, the full repertoire of miRNAs in pig remains to be elucidated. To identify porcine miRNAs potentially involved in myogenesis and adipogenesis, we constructed small RNA cDNA libraries from skeletal muscle and adipose tissue and identified 89 distinct miRNAs that are conserved in pig, of which 15 were new. Expression analysis of all newly identified and selected known porcine miRNAs revealed that some miRNAs were enriched in a tissue-specific manner, whereas others were expressed ubiquitously in the porcine tissues examined. Our results expand the number of known porcine miRNAs and provide useful information for further investigating the biological functions of miRNAs associated with growth and development of skeletal muscle or adipose tissue in pig.
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