Phenolic Compounds from Pueraria lobata Protect PC12 Cells against A beta-induced Toxicity
DC Field | Value | Language |
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dc.contributor.author | Choi, Yun-hyeok | - |
dc.contributor.author | Hong, Seong Su | - |
dc.contributor.author | Shin, Yu Su | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Park, So-Young | - |
dc.contributor.author | Lee, Dongho | - |
dc.date.accessioned | 2021-09-07T23:56:10Z | - |
dc.date.available | 2021-09-07T23:56:10Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115608 | - |
dc.description.abstract | Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of A beta-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED50 values of 33.7 and 27.8 mu M, respectively. In addition, a new coumestan, 2-(alpha,alpha-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | ISOFLAVONES | - |
dc.title | Phenolic Compounds from Pueraria lobata Protect PC12 Cells against A beta-induced Toxicity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1007/s12272-010-1014-7 | - |
dc.identifier.scopusid | 2-s2.0-78449264283 | - |
dc.identifier.wosid | 000283563200016 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.33, no.10, pp.1651 - 1654 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 33 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1651 | - |
dc.citation.endPage | 1654 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001488955 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | ISOFLAVONES | - |
dc.subject.keywordAuthor | Pueraria lobata | - |
dc.subject.keywordAuthor | Fabaceae | - |
dc.subject.keywordAuthor | 2-(alpha,alpha-dimethylallyl)coumestrol | - |
dc.subject.keywordAuthor | Isoflavone | - |
dc.subject.keywordAuthor | Beta-amyloid | - |
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