Phenolic Compounds from Pueraria lobata Protect PC12 Cells against A beta-induced Toxicity
- Authors
- Choi, Yun-hyeok; Hong, Seong Su; Shin, Yu Su; Hwang, Bang Yeon; Park, So-Young; Lee, Dongho
- Issue Date
- 10월-2010
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Pueraria lobata; Fabaceae; 2-(alpha,alpha-dimethylallyl)coumestrol; Isoflavone; Beta-amyloid
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.33, no.10, pp.1651 - 1654
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 33
- Number
- 10
- Start Page
- 1651
- End Page
- 1654
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115608
- DOI
- 10.1007/s12272-010-1014-7
- ISSN
- 0253-6269
- Abstract
- Bioassay-guided fractionation of the EtOAc-soluble extract of Pueraria lobata based on the inhibition of A beta-induced toxicity in PC12 cells resulted in the isolation of four known active compounds, genistein (8), biochanin A (9), sissotrin (10), and puerol B (11). Of these, genistein (8) and biochanin A (9) exhibited potent neuroprotective effects with ED50 values of 33.7 and 27.8 mu M, respectively. In addition, a new coumestan, 2-(alpha,alpha-dimethylallyl)coumestrol (1) was isolated and characterized, but proved to be inactive, as were additional seven known compounds. The structure of new compound 1 was determined using spectroscopic techniques.
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Collections - Graduate School > Department of Plant Biotechnology > 1. Journal Articles
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