Genetically modified Bifidobacterium displaying Salmonella-antigen protects mice from lethal challenge of Salmonella Typhimurium in a murine typhoid fever model
DC Field | Value | Language |
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dc.contributor.author | Yamamoto, Sakura | - |
dc.contributor.author | Wada, Jun | - |
dc.contributor.author | Katayama, Takane | - |
dc.contributor.author | Jikimoto, Takumi | - |
dc.contributor.author | Nakamura, Masakuni | - |
dc.contributor.author | Kinoshita, Shohiro | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.contributor.author | Kawabata, Masato | - |
dc.contributor.author | Shirakawa, Toshiro | - |
dc.date.accessioned | 2021-09-08T00:10:29Z | - |
dc.date.available | 2021-09-08T00:10:29Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09-24 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115661 | - |
dc.description.abstract | We developed a novel vaccine platform utilizing Bifidobacterium as an antigen delivery vehicle for mucosal immunization. Genetically modified Bifidobacterium longum displaying Salmonella-flagellin on the cell surface was constructed for the oral typhoid vaccine. The efficiency of this vaccine was evaluated in a murine model of typhoid fever. We then orally administered 2.5 x 10(7) CFU of the recombinant Bifidobacterium longum (vaccine) or parental Bifidobacterium longum, or PBS to BALB/C mice every other day for 2 weeks. After the administration, a total of 42 mice (14 mice in each group) were challenged with Salmonella Typhimurium (1.0 x 10(7) CFU/mouse). While 12 mice in the PBS group, and 9 in the parental Bifidobacterium longum group died (median survival: 14 and 25 days), only two in the vaccine group died. These data support that our genetically modified Bifidobacterium antigen delivery system offers a promising vaccine platform for inducing efficient mucosal immunity. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | T-CELLS | - |
dc.subject | MUCOSAL | - |
dc.subject | VACCINE | - |
dc.subject | LIVE | - |
dc.subject | LACTOBACILLUS | - |
dc.subject | INFECTION | - |
dc.subject | DELIVERY | - |
dc.subject | VECTORS | - |
dc.subject | IMMUNOGENICITY | - |
dc.title | Genetically modified Bifidobacterium displaying Salmonella-antigen protects mice from lethal challenge of Salmonella Typhimurium in a murine typhoid fever model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kyung-Mi | - |
dc.identifier.doi | 10.1016/j.vaccine.2010.08.007 | - |
dc.identifier.scopusid | 2-s2.0-77956494584 | - |
dc.identifier.wosid | 000282734800005 | - |
dc.identifier.bibliographicCitation | VACCINE, v.28, no.41, pp.6684 - 6691 | - |
dc.relation.isPartOf | VACCINE | - |
dc.citation.title | VACCINE | - |
dc.citation.volume | 28 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | 6684 | - |
dc.citation.endPage | 6691 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | VECTORS | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | MUCOSAL | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | LIVE | - |
dc.subject.keywordPlus | LACTOBACILLUS | - |
dc.subject.keywordAuthor | Bifidobacterium | - |
dc.subject.keywordAuthor | Mucosal vaccine | - |
dc.subject.keywordAuthor | Salmonella | - |
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