MKP1 Regulates the Induction of MCP1 by Streptococcus pneumoniae Pneumolysin in Human Epithelial Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Hee-Sung | - |
dc.contributor.author | Yoo, In-Hwa | - |
dc.contributor.author | Kim, Yong-Jae | - |
dc.contributor.author | Lee, Ji-Yun | - |
dc.contributor.author | Kim, Hyong-Bai | - |
dc.contributor.author | Jin, Shouguang | - |
dc.contributor.author | Ha, Un-Hwan | - |
dc.date.accessioned | 2021-09-08T00:27:53Z | - |
dc.date.available | 2021-09-08T00:27:53Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115754 | - |
dc.description.abstract | Epithelial cells act as the first line of host defense against microbes by producing a range of different molecules for clearance. Chemokines facilitate the clearance of invaders through the recruitment of leukocytes. Thus, upregulation of chemokine expression represents an important innate host defense response against invading microbes such as Streptococcus pneumoniae. In this study, we report that the expression of Monocyte Chemotactic Protein 1 (MCP1) was highly induced in response to S. pneumoniae in vitro and in vivo. Among numerous virulence factors, pneumococcal pneumolysin was found to be the major factor responsible for this induction. Furthermore, MCP1 induction was mediated by the p38 mitogen-activated protein kinase (MAPK) whose activation was controlled by MAPK phosphatase 1 (MKP1). Therefore, this study reveals novel roles of pneumolysin in mediating MKP1 expression for the regulation of MCP1 expression in human epithelial cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.subject | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject | CONJUGATE VACCINE FORMULATION | - |
dc.subject | INNATE IMMUNE-RESPONSES | - |
dc.subject | PNEUMOCOCCAL SEROGROUPS | - |
dc.subject | MONONUCLEAR PHAGOCYTES | - |
dc.subject | CHEMOTACTIC PROTEIN-1 | - |
dc.subject | CYTOKINE PRODUCTION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | HUMAN NEUTROPHILS | - |
dc.title | MKP1 Regulates the Induction of MCP1 by Streptococcus pneumoniae Pneumolysin in Human Epithelial Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyong-Bai | - |
dc.contributor.affiliatedAuthor | Ha, Un-Hwan | - |
dc.identifier.doi | 10.1007/s10059-010-0113-0 | - |
dc.identifier.scopusid | 2-s2.0-78049276670 | - |
dc.identifier.wosid | 000282232200011 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.30, no.3, pp.263 - 270 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 263 | - |
dc.citation.endPage | 270 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001488345 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | - |
dc.subject.keywordPlus | CONJUGATE VACCINE FORMULATION | - |
dc.subject.keywordPlus | INNATE IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | PNEUMOCOCCAL SEROGROUPS | - |
dc.subject.keywordPlus | MONONUCLEAR PHAGOCYTES | - |
dc.subject.keywordPlus | CHEMOTACTIC PROTEIN-1 | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | HUMAN NEUTROPHILS | - |
dc.subject.keywordAuthor | MCP1 | - |
dc.subject.keywordAuthor | MKP1 | - |
dc.subject.keywordAuthor | p38 | - |
dc.subject.keywordAuthor | pneumolysin | - |
dc.subject.keywordAuthor | Streptococcus pneumoniae | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.