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MKP1 Regulates the Induction of MCP1 by Streptococcus pneumoniae Pneumolysin in Human Epithelial Cells

Authors
Shin, Hee-SungYoo, In-HwaKim, Yong-JaeLee, Ji-YunKim, Hyong-BaiJin, ShouguangHa, Un-Hwan
Issue Date
9월-2010
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Keywords
MCP1; MKP1; p38; pneumolysin; Streptococcus pneumoniae
Citation
MOLECULES AND CELLS, v.30, no.3, pp.263 - 270
Indexed
SCIE
SCOPUS
KCI
Journal Title
MOLECULES AND CELLS
Volume
30
Number
3
Start Page
263
End Page
270
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115754
DOI
10.1007/s10059-010-0113-0
ISSN
1016-8478
Abstract
Epithelial cells act as the first line of host defense against microbes by producing a range of different molecules for clearance. Chemokines facilitate the clearance of invaders through the recruitment of leukocytes. Thus, upregulation of chemokine expression represents an important innate host defense response against invading microbes such as Streptococcus pneumoniae. In this study, we report that the expression of Monocyte Chemotactic Protein 1 (MCP1) was highly induced in response to S. pneumoniae in vitro and in vivo. Among numerous virulence factors, pneumococcal pneumolysin was found to be the major factor responsible for this induction. Furthermore, MCP1 induction was mediated by the p38 mitogen-activated protein kinase (MAPK) whose activation was controlled by MAPK phosphatase 1 (MKP1). Therefore, this study reveals novel roles of pneumolysin in mediating MKP1 expression for the regulation of MCP1 expression in human epithelial cells.
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