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Neuron-Specific Expression of atp6v0c2 in Zebrafish CNS

Authors
Chung, Ah-YoungKim, Myoung-JinKim, DohyunBang, SangsuHwang, Sun WookLim, Chae SeungLee, SanggyuPark, Hae-ChulHuh, Tae-Lin
Issue Date
9월-2010
Publisher
WILEY
Keywords
V-ATPase; neuron; Notch signaling; zebrafish
Citation
DEVELOPMENTAL DYNAMICS, v.239, no.9, pp.2501 - 2508
Indexed
SCIE
SCOPUS
Journal Title
DEVELOPMENTAL DYNAMICS
Volume
239
Number
9
Start Page
2501
End Page
2508
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115787
DOI
10.1002/dvdy.22383
ISSN
1058-8388
Abstract
Vacuolar ATPase (V-ATPase) is a multi-subunit enzyme that plays an important role in the acidification of a variety of intracellular compartments. ATP6V0C is subunit c of the V-o domain that forms the proteolipid pore of the enzyme. In the present study, we investigated the neuron-specific expression of atp6v0c2, a novel isoform of the V-ATPase c-subunit, during the development of the zebrafish CNS. Zebrafish atp6v0c2 was isolaled from a genome-wide analysis of the zebrafish mib(ta52b) mutant designed to identify genes differentially regulated by Notch signaling. Whole-mount in situ hybridization revealed that atp6v0c2 is expressed in a subset of CNS neurons beginning several hours after the emergence of post-mitotic neurons. The ATP6V0C2 protein is co-localized with the presynaptic vesicle marker, SV2, suggesting that it is involved in neurotransmitter storage and/or secretion in neurons. In addition, the loss-of-function experiment suggests that ATP6VOC2 is involved in the control of neuronal excitability. Developmental Dynamics 239:2501-2508, 2010. (C) 2010 Wiley-Liss, Inc.
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