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Support Vector Machine Based Classification of 3-Dimensional Protein Physicochemical Environments for Automated Function Annotation

Authors
Min, HyeyoungYu, SeunghakLee, TaehoonYoon, Sungroh
Issue Date
Sep-2010
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Protein function; 3-dimensional structure; FEATURE; Dimensionality reduction; Normalization; Support vector machine
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.33, no.9, pp.1451 - 1459
Indexed
SCIE
SCOPUS
KCI
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
33
Number
9
Start Page
1451
End Page
1459
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115840
DOI
10.1007/s12272-010-0920-z
ISSN
0253-6269
Abstract
The knowledge of protein functions as well as structures is critical for drug discovery and development. The FEATURE system developed at Stanford is an effective tool for characterizing and classifying local environments in proteins. FEATURE utilizes vectors of a fixed dimension to represent the physicochemical properties around a residue. Functional sites and non-sites are identified by classifying such vectors using the Naive Bayes classifier. In this paper, we improve the FEATURE framework in several ways so that it can be more flexible, robust and accurate. The new tool can handle vectors of a user-specified dimension and can suppress noise effectively, with little loss of important signals, by employing dimensionality reduction. Furthermore, our approach utilizes the support vector machine for a more accurate classification. According to the results of our thorough experiments, the proposed new approach outperformed the original tool by 20.13% and 13.42% with respect to true and false positive rates, respectively.
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