The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis
- Authors
- Jung, Sundo; Park, Yoon-Kyung; Shin, Jung Hoon; Lee, Hyunji; Kim, Soo-Young; Lee, Gap Ryol; Park, Se-Ho
- Issue Date
- 31-8월-2010
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- antigen-presenting cells; antigens; arthritis; CD1d; experimental; immune tolerance; natural killer T-cells
- Citation
- EXPERIMENTAL AND MOLECULAR MEDICINE, v.42, no.8, pp.547 - 554
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- EXPERIMENTAL AND MOLECULAR MEDICINE
- Volume
- 42
- Number
- 8
- Start Page
- 547
- End Page
- 554
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115852
- DOI
- 10.3858/emm.2010.42.8.055
- ISSN
- 1226-3613
- Abstract
- TGF-beta-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d(+/-) or CD1d(-/-) mice, unlike CD1d(+/-) APCs, CD1d(-/-) Tol-APCs failed to suppress CIA. More specifically, CD1d(-/-) Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.
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