Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
DC Field | Value | Language |
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dc.contributor.author | Chandana, Ediriweera P. S. | - |
dc.contributor.author | Maeda, Yasuhiro | - |
dc.contributor.author | Ueda, Akihiko | - |
dc.contributor.author | Kiyonari, Hiroshi | - |
dc.contributor.author | Oshima, Naoko | - |
dc.contributor.author | Yamamoto, Mako | - |
dc.contributor.author | Kondo, Shunya | - |
dc.contributor.author | Oh, Junseo | - |
dc.contributor.author | Takahashi, Rei | - |
dc.contributor.author | Yoshida, Yoko | - |
dc.contributor.author | Kawashima, Satoshi | - |
dc.contributor.author | Alexander, David B. | - |
dc.contributor.author | Kitayama, Hitoshi | - |
dc.contributor.author | Takahashi, Chiaki | - |
dc.contributor.author | Tabata, Yasuhiko | - |
dc.contributor.author | Matsuzaki, Tomoko | - |
dc.contributor.author | Noda, Makoto | - |
dc.date.accessioned | 2021-09-08T01:01:17Z | - |
dc.date.available | 2021-09-08T01:01:17Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-08-06 | - |
dc.identifier.issn | 1471-213X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115894 | - |
dc.description.abstract | Background: Developmental angiogenesis proceeds through multiple morphogenetic events including sprouting, intussusception, and pruning. Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10.5 with halted vascular development; however, the mechanisms by which this phenotype arises remain unclear. Results: We found that Reck is abundantly expressed in the cells associated with blood vessels undergoing angiogenesis or remodelling in the uteri of pregnant female mice. Some of the Reck-positive vessels show morphological features consistent with non-sprouting angiogenesis. Treatment with a vector expressing a small hairpin RNA against Reck severely disrupts the formation of blood vessels with a compact, round lumen. Similar defects were found in the vasculature of Reck-deficient or Reck conditional knockout embryos. Conclusions: Our findings implicate Reck in vascular remodeling, possibly through non-sprouting angiogenesis, in both maternal and embyornic tissues. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | MMP-REGULATOR RECK | - |
dc.subject | INTUSSUSCEPTIVE ANGIOGENESIS | - |
dc.subject | CARDIOVASCULAR DEVELOPMENT | - |
dc.subject | MATRIX-METALLOPROTEINASE | - |
dc.subject | IMPLANTATION | - |
dc.subject | NOTCH | - |
dc.subject | MOUSE | - |
dc.subject | CELLS | - |
dc.subject | RECOMBINATION | - |
dc.subject | MORPHOGENESIS | - |
dc.title | Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Junseo | - |
dc.identifier.doi | 10.1186/1471-213X-10-84 | - |
dc.identifier.scopusid | 2-s2.0-77955188882 | - |
dc.identifier.wosid | 000282740000001 | - |
dc.identifier.bibliographicCitation | BMC DEVELOPMENTAL BIOLOGY, v.10 | - |
dc.relation.isPartOf | BMC DEVELOPMENTAL BIOLOGY | - |
dc.citation.title | BMC DEVELOPMENTAL BIOLOGY | - |
dc.citation.volume | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Developmental Biology | - |
dc.relation.journalWebOfScienceCategory | Developmental Biology | - |
dc.subject.keywordPlus | MMP-REGULATOR RECK | - |
dc.subject.keywordPlus | INTUSSUSCEPTIVE ANGIOGENESIS | - |
dc.subject.keywordPlus | CARDIOVASCULAR DEVELOPMENT | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | NOTCH | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RECOMBINATION | - |
dc.subject.keywordPlus | MORPHOGENESIS | - |
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