Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice
- Authors
- Chandana, Ediriweera P. S.; Maeda, Yasuhiro; Ueda, Akihiko; Kiyonari, Hiroshi; Oshima, Naoko; Yamamoto, Mako; Kondo, Shunya; Oh, Junseo; Takahashi, Rei; Yoshida, Yoko; Kawashima, Satoshi; Alexander, David B.; Kitayama, Hitoshi; Takahashi, Chiaki; Tabata, Yasuhiko; Matsuzaki, Tomoko; Noda, Makoto
- Issue Date
- 6-8월-2010
- Publisher
- BMC
- Citation
- BMC DEVELOPMENTAL BIOLOGY, v.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- BMC DEVELOPMENTAL BIOLOGY
- Volume
- 10
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115894
- DOI
- 10.1186/1471-213X-10-84
- ISSN
- 1471-213X
- Abstract
- Background: Developmental angiogenesis proceeds through multiple morphogenetic events including sprouting, intussusception, and pruning. Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10.5 with halted vascular development; however, the mechanisms by which this phenotype arises remain unclear. Results: We found that Reck is abundantly expressed in the cells associated with blood vessels undergoing angiogenesis or remodelling in the uteri of pregnant female mice. Some of the Reck-positive vessels show morphological features consistent with non-sprouting angiogenesis. Treatment with a vector expressing a small hairpin RNA against Reck severely disrupts the formation of blood vessels with a compact, round lumen. Similar defects were found in the vasculature of Reck-deficient or Reck conditional knockout embryos. Conclusions: Our findings implicate Reck in vascular remodeling, possibly through non-sprouting angiogenesis, in both maternal and embyornic tissues.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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