Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice
DC Field | Value | Language |
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dc.contributor.author | Lee, Il-ok | - |
dc.contributor.author | Lim, Eui-sung | - |
dc.date.accessioned | 2021-09-08T01:10:31Z | - |
dc.date.available | 2021-09-08T01:10:31Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 1671-4083 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115947 | - |
dc.description.abstract | Aim: To investigate the effects of GABA and glycine on analgesia in the central nervous system. Methods: Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. Results: The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site. Conclusion: Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SHANGHAI INST MATERIA MEDICA | - |
dc.subject | SPINAL DORSAL-HORN | - |
dc.subject | PROSTAGLANDIN E(2) | - |
dc.subject | TACTILE ALLODYNIA | - |
dc.subject | CONSCIOUS MICE | - |
dc.subject | AMINO-ACIDS | - |
dc.subject | RECEPTORS | - |
dc.subject | GABA | - |
dc.subject | STRYCHNINE | - |
dc.subject | NEURONS | - |
dc.subject | MOUSE | - |
dc.title | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Il-ok | - |
dc.identifier.doi | 10.1038/aps.2010.82 | - |
dc.identifier.scopusid | 2-s2.0-77955459344 | - |
dc.identifier.wosid | 000280617100003 | - |
dc.identifier.bibliographicCitation | ACTA PHARMACOLOGICA SINICA, v.31, no.8, pp.907 - 914 | - |
dc.relation.isPartOf | ACTA PHARMACOLOGICA SINICA | - |
dc.citation.title | ACTA PHARMACOLOGICA SINICA | - |
dc.citation.volume | 31 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 907 | - |
dc.citation.endPage | 914 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SPINAL DORSAL-HORN | - |
dc.subject.keywordPlus | PROSTAGLANDIN E(2) | - |
dc.subject.keywordPlus | TACTILE ALLODYNIA | - |
dc.subject.keywordPlus | CONSCIOUS MICE | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | GABA | - |
dc.subject.keywordPlus | STRYCHNINE | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordAuthor | allodynia | - |
dc.subject.keywordAuthor | hyperalgesia | - |
dc.subject.keywordAuthor | bicuculline | - |
dc.subject.keywordAuthor | glycine | - |
dc.subject.keywordAuthor | intracisternal | - |
dc.subject.keywordAuthor | intrathecal drug delivery | - |
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