Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice
- Authors
- Lee, Il-ok; Lim, Eui-sung
- Issue Date
- 8월-2010
- Publisher
- SHANGHAI INST MATERIA MEDICA
- Keywords
- allodynia; hyperalgesia; bicuculline; glycine; intracisternal; intrathecal drug delivery
- Citation
- ACTA PHARMACOLOGICA SINICA, v.31, no.8, pp.907 - 914
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA PHARMACOLOGICA SINICA
- Volume
- 31
- Number
- 8
- Start Page
- 907
- End Page
- 914
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/115947
- DOI
- 10.1038/aps.2010.82
- ISSN
- 1671-4083
- Abstract
- Aim: To investigate the effects of GABA and glycine on analgesia in the central nervous system. Methods: Glycine, taurine, or muscimol was injected with bicuculline into the cistern magna or the lumbar subarachnoidal space in ICR mice. The effects on bicuculline-induced allodynia in a touch-evoked agitation test and on pain threshold index in a hot-plate test were assessed. Results: The dosages of the amino acids administered with bicuculline had no effect on motor behavior in conscious mice. Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia. Glycine, taurine, and muscimol all antagonized the effects induced by bicuculline in the hot-plate test, regardless of the administration site. Conclusion: Glycine, taurine, and muscimol were found to have anti-allodynic and anti-thermal hyperalgesic properties in vivo. These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.
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