Class II beta-tubulin is a novel marker for human tonsillar M cells and follicular dendritic cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Ju-Han | - |
dc.contributor.author | Kong, Su-Kang | - |
dc.contributor.author | Wu, Zheng-Sheng | - |
dc.contributor.author | Wu, Qiang | - |
dc.contributor.author | Choe, Jongseon | - |
dc.contributor.author | Cho, Hyun Yee | - |
dc.contributor.author | Ha, Seung Yeon | - |
dc.contributor.author | Kee, Sun Ho | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.date.accessioned | 2021-09-08T01:13:30Z | - |
dc.date.available | 2021-09-08T01:13:30Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/115963 | - |
dc.description.abstract | Objective: Membranous (M) cell of the human palatine tonsil is an antigen entry site for mucosal infection, but its location is obscure in histological sections. Recently, a microarray analysis has demonstrated that clusterin, annexin A5, CD44, MMP14, and beta-tubulin are candidate genes of M cell marker in mice. Among these genes, we here describe class II beta-tubulin as a new marker for human tonsillar M cells and follicular dendritic cells (FDCs), and present its usefulness for diagnosis of angioimmunoblastic T-cell lymphomas (AILTs). Materials and methods: Immunohistochemistry and Western blotting for class II beta-tubulin were performed using 81 cases of lymphoid, gastrointestinal and thyroid tissues, and an FDC cell line, respectively. Double immunostaining with clusterin and class II beta-tubulin were carried out. Results: Class II beta-tubulin localized the M cells and FDCs in the palatine tonsils (10/10, 100%) and adenoids (10/10, 100%). It was colocalized with clusterin in the palatine tonsils. However, class II beta-tubulin staining did not identify intestinal M cells in the intestines. Immunoblot analysis revealed that class II beta-tubulin expression was upregulated in HK cells, a normal FDC cell line. Class II beta-tubulin immunostaining highlighted hyperplastic FDC meshworks in all AILTs (14/14, 100%). Conclusion: Class II beta-tubulin is a specific histochemical marker for human tonsillar M cells and FDCs. Thus, class II beta-tubulin immunostaining may be useful to identify tonsillar M cells and to diagnose FDC proliferative lesions such as AILT. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | EPITHELIAL M-CELLS | - |
dc.subject | GERMINAL CENTER | - |
dc.subject | B-CELLS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | PROLIFERATION | - |
dc.subject | LYMPHOMA | - |
dc.subject | LINE | - |
dc.subject | EXPRESSION | - |
dc.subject | MOLECULE | - |
dc.subject | ORIGIN | - |
dc.title | Class II beta-tubulin is a novel marker for human tonsillar M cells and follicular dendritic cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Ju-Han | - |
dc.contributor.affiliatedAuthor | Kee, Sun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Young-Sik | - |
dc.identifier.doi | 10.1111/j.1600-0714.2009.00865.x | - |
dc.identifier.scopusid | 2-s2.0-77955255723 | - |
dc.identifier.wosid | 000280644100004 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ORAL PATHOLOGY & MEDICINE, v.39, no.7, pp.533 - 539 | - |
dc.relation.isPartOf | JOURNAL OF ORAL PATHOLOGY & MEDICINE | - |
dc.citation.title | JOURNAL OF ORAL PATHOLOGY & MEDICINE | - |
dc.citation.volume | 39 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 533 | - |
dc.citation.endPage | 539 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Dentistry, Oral Surgery & Medicine | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | EPITHELIAL M-CELLS | - |
dc.subject.keywordPlus | GERMINAL CENTER | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | LYMPHOMA | - |
dc.subject.keywordPlus | LINE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MOLECULE | - |
dc.subject.keywordPlus | ORIGIN | - |
dc.subject.keywordAuthor | follicular dendritic cell | - |
dc.subject.keywordAuthor | M cell | - |
dc.subject.keywordAuthor | palatine tonsil | - |
dc.subject.keywordAuthor | tubulin | - |
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