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Effects of Body Composition, Leptin, and Adiponectin on Bone Mineral Density in Prepubertal Girls

Authors
Rhie, Young JunLee, Kee HyoungChung, So ChungKim, Ho SeongKim, Duk Hee
Issue Date
8월-2010
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Bone Density; Body Composition; Leptin; Adiponectin; Obesity
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.8, pp.1187 - 1190
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
25
Number
8
Start Page
1187
End Page
1190
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/115969
DOI
10.3346/jkms.2010.25.8.1187
ISSN
1011-8934
Abstract
Body weight is positively associated with bone mineral density but the relationship between obesity and bone mineral density is unclear. Leptin and adiponectin are potential independent contributors to bone mineral density. We assessed the correlations of body composition, leptin and adiponectin with bone mineral density, and whether leptin, adiponectin and body composition determine bone mineral density independently in prepubertal girls. Forty-eight prepubertal girls were classified into obese and control groups by body mass index. Serum leptin and adiponectin levels were determined by enzyme immunoassay. Bone mineral density was measured using dual energy radiography absorptiometry and body composition was measured using bioelectrical impedance analysis. Lean and fat mass, and leptin were positively correlated with bone mineral density. Lean mass was a positive independent predictor of femoral and L-spine bone mineral density. Serum leptin was a postivie independent predictor of femoral bone mineral density. Fat mass was a negative independent predictor of femoral bone mineral density. In prepubertal girls, lean mass has a favorable effect on bone mineral density. Fat mass seems not to protect the bone structure against osteoporosis, despite increased mechanical loading. Serum leptin may play a biological role in regulating bone metabolism.
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