Effect of TGF-beta 1 polymorphism on the susceptibility to schizophrenia and treatment response to atypical antipsychotic agent
DC Field | Value | Language |
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dc.contributor.author | Lee, Hwa-Young | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-09-08T01:25:46Z | - |
dc.date.available | 2021-09-08T01:25:46Z | - |
dc.date.created | 2021-06-14 | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 0924-2708 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116025 | - |
dc.description.abstract | Objective: Several studies have suggested that cytokine alterations could be related to the pathophysiology of schizophrenia. Transforming growth factor-beta1 (TGF-beta 1) is believed to be an important factor in regulation of inflammatory responses and to have anti-inflammatory effects. TGF-beta 1 also has trophic effects on dopaminergic neurons. We tested the hypothesis TGF-beta 1 is associated with the pathophysiology of schizophrenia. Methods: The polymorphisms at codon 10 (T869C) and codon 25 (G915C) of TGF-beta 1 were analysed in 99 schizophrenia patients and 130 normal controls. At baseline and after 8 weeks of treatment, clinical symptoms were evaluated on Positive and Negative Syndrome Scale (PANSS). Results: None of the subjects were polymorphic at codon 25. However, the C allele at codon 10 was more frequent in schizophrenia (p = 0.05). Although schizophrenia group showed a higher tendency of allele frequency in the subjects with C allele (p = 0.05), the allelic difference did not reach statistical significance after correction for multiple comparisons (p = 0.1). PANSS scores showed no significant correlation with genotypes. The genotype distribution was not significantly different between responders and non-responders. However, the C allele was more frequent among responders (p = 0.03). Conclusion: These results suggest that the TGF-beta 1 polymorphism is associated with therapeutic response to antipsychotics. However, further studies with larger numbers of subjects are needed to confirm the effect of TGF-beta 1 in schizophrenia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | TRANSFORMING GROWTH-FACTOR-BETA-1 GENE | - |
dc.subject | MIDBRAIN DOPAMINERGIC-NEURONS | - |
dc.subject | T-HELPER TYPE-1 | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | CEREBROSPINAL-FLUID | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | ASSOCIATION | - |
dc.subject | FACTOR-BETA(1) | - |
dc.title | Effect of TGF-beta 1 polymorphism on the susceptibility to schizophrenia and treatment response to atypical antipsychotic agent | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1111/j.1601-5215.2009.00435.x | - |
dc.identifier.scopusid | 2-s2.0-77954355281 | - |
dc.identifier.wosid | 000279437200003 | - |
dc.identifier.bibliographicCitation | ACTA NEUROPSYCHIATRICA, v.22, no.4, pp.174 - 179 | - |
dc.relation.isPartOf | ACTA NEUROPSYCHIATRICA | - |
dc.citation.title | ACTA NEUROPSYCHIATRICA | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 174 | - |
dc.citation.endPage | 179 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | TRANSFORMING GROWTH-FACTOR-BETA-1 GENE | - |
dc.subject.keywordPlus | MIDBRAIN DOPAMINERGIC-NEURONS | - |
dc.subject.keywordPlus | T-HELPER TYPE-1 | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | FACTOR-BETA(1) | - |
dc.subject.keywordAuthor | antipsychotic | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | schizophrenia | - |
dc.subject.keywordAuthor | transforming growth factor-beta1 | - |
dc.subject.keywordAuthor | treatment response | - |
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