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Effect of TGF-beta 1 polymorphism on the susceptibility to schizophrenia and treatment response to atypical antipsychotic agent

Authors
Lee, Hwa-YoungKim, Yong-Ku
Issue Date
8월-2010
Publisher
WILEY-BLACKWELL
Keywords
antipsychotic; polymorphism; schizophrenia; transforming growth factor-beta1; treatment response
Citation
ACTA NEUROPSYCHIATRICA, v.22, no.4, pp.174 - 179
Indexed
SCIE
SCOPUS
Journal Title
ACTA NEUROPSYCHIATRICA
Volume
22
Number
4
Start Page
174
End Page
179
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116025
DOI
10.1111/j.1601-5215.2009.00435.x
ISSN
0924-2708
Abstract
Objective: Several studies have suggested that cytokine alterations could be related to the pathophysiology of schizophrenia. Transforming growth factor-beta1 (TGF-beta 1) is believed to be an important factor in regulation of inflammatory responses and to have anti-inflammatory effects. TGF-beta 1 also has trophic effects on dopaminergic neurons. We tested the hypothesis TGF-beta 1 is associated with the pathophysiology of schizophrenia. Methods: The polymorphisms at codon 10 (T869C) and codon 25 (G915C) of TGF-beta 1 were analysed in 99 schizophrenia patients and 130 normal controls. At baseline and after 8 weeks of treatment, clinical symptoms were evaluated on Positive and Negative Syndrome Scale (PANSS). Results: None of the subjects were polymorphic at codon 25. However, the C allele at codon 10 was more frequent in schizophrenia (p = 0.05). Although schizophrenia group showed a higher tendency of allele frequency in the subjects with C allele (p = 0.05), the allelic difference did not reach statistical significance after correction for multiple comparisons (p = 0.1). PANSS scores showed no significant correlation with genotypes. The genotype distribution was not significantly different between responders and non-responders. However, the C allele was more frequent among responders (p = 0.03). Conclusion: These results suggest that the TGF-beta 1 polymorphism is associated with therapeutic response to antipsychotics. However, further studies with larger numbers of subjects are needed to confirm the effect of TGF-beta 1 in schizophrenia.
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