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Anti-diabetic effects of lemon balm (Melissa officinalis) essential oil on glucose- and lipid-regulating enzymes in type 2 diabetic mice

Authors
Chung, Mi JaCho, Sung-YunBhuiyan, Muhammad Javidul HaqueKim, Kyoung HeonLee, Sung-Joon
Issue Date
28-7월-2010
Publisher
CAMBRIDGE UNIV PRESS
Keywords
Lemon balm (Melissa officinalis); Hyperglycaemic effects; Glucokinase; GLUT4; Sterol regulatory element-binding protein-1c
Citation
BRITISH JOURNAL OF NUTRITION, v.104, no.2, pp.180 - 188
Indexed
SCIE
SCOPUS
Journal Title
BRITISH JOURNAL OF NUTRITION
Volume
104
Number
2
Start Page
180
End Page
188
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116042
DOI
10.1017/S0007114510001765
ISSN
0007-1145
Abstract
The antioxidant activity of lemon balm (Melissa officinalis) essential oil (LBEO) on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and its hypoglycaemic effect in dbldb mice were investigated. LBEO scavenged 97 % of DPPH radicals at a 270-fold dilution. Mice administered LBEO (0.015 mg/d) for 6 weeks showed significantly reduced blood glucose (65%; P<0.05) and TAG concentrations, improved glucose tolerance, as assessed by an oral glucose tolerance test, and significantly higher serum insulin levels, compared with the control group. The hypoglycaemic mechanism of LBEO was further explored via gene and protein expression analyses using RT-PCR and Western blotting, respectively. Among all glucose metabolism-related genes studied, hepatic glucokinase and GLUT4, as well as adipocyte GLUT4, PPAR-gamma, PPAR-alpha and SREBP-1c expression, were significantly up-regulated, whereas glucose-6-phosphatase and phosphoenolpyruvate carboxykinase expression was down-regulated in the livers of the LBEO group. The results further suggest that LBEO administered at low concentrations is an efficient hypoglycaemic agent, probably due to enhanced glucose uptake and metabolism in the liver and adipose tissue and the inhibition of gluconeogenesis in the liver.
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생명과학대학 (식품공학과)
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