Gadoxetic Acid (Gd-EOB-DTPA)-Enhanced MRI versus Gadobenate Dimeglumine (Gd-BOPTA)-Enhanced MRI for Preoperatively Detecting Hepatocellular Carcinoma: an Initial Experience
- Authors
- Park, Yulri; Kim, Seong Hyun; Kim, Seung Hoon; Jeon, Yong Hwan; Lee, Jongmee; Kim, Min Ju; Choi, Dongil; Lee, Won Jae; Kim, Heejung; Koo, Ji Hyun; Lim, Hyo Keun
- Issue Date
- 7월-2010
- Publisher
- KOREAN RADIOLOGICAL SOC
- Keywords
- Hepatocellular carcinoma (HCC); Gadoxetic acid-enhanced MRI; Gadobenate dimeglumine-enhanced MRI
- Citation
- KOREAN JOURNAL OF RADIOLOGY, v.11, no.4, pp.433 - 440
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF RADIOLOGY
- Volume
- 11
- Number
- 4
- Start Page
- 433
- End Page
- 440
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/116085
- DOI
- 10.3348/kjr.2010.11.4.433
- ISSN
- 1229-6929
- Abstract
- Objective: This study was designed to compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with gadobenate dimeglumine-enhanced MRI for preoperatively detecting hepatocellular carcinoma (HCC). Materials and Methods: Eighteen consecutive patients (17 men and one woman, age range: 31-73 years) with 22 HCCs underwent examinations with gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI on a 3.0-Tesla unit. The diagnosis of HOC was established after surgical resection and pathological conformation. Three observers independently reviewed each MR image in a random order on a tumor-by-tumor basis. The diagnostic accuracy of these techniques for the detection of HOC was assessed by performing an alternative free-response receiver operating characteristic (ROC) analysis. The sensitivity and positive predictive values were evaluated. Results: The average value of the area under the ROC curve (Az) for gadoxetic acid enhanced MRI (0.887) was not significantly different from the Az (0.899) for gadobenate dimeglumine-enhanced MRI (p > 0.05). The overall sensitivities of gadoxetic acid enhanced MRI and gadobenate dimeglumine-enhanced MRI were 80% and 83%, respectively, with no significant difference (p > 0.05). The differences of the positive predictive values for the two contrast agents for each observer were not statistically significant (p > 0.05). Conclusion: The diagnostic performance of gadoxetic acid-enhanced MRI and gadobenate dimeglumine-enhanced MRI for preoperatively detecting HOC is quite similar.
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