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Neuroprotective effects of constituents of Eragrostis ferruginea against A beta-induced toxicity in PC12 cells
- Authors
- Na, Chae Sun; Hong, Seong Su; Choi, Yun-Hyeok; Lee, Yong Ho; Hong, Sun Hee; Lim, Ji-Youn; Kang, Byeong Hoa; Park, So-Young; Lee, Dongho
- Issue Date
- Jul-2010
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Eragrostis ferruginea; Poaceae; 7-Demethylageconyflavone A; Beta-amyloid; Neuroprotection
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.33, no.7, pp.999 - 1003
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 33
- Number
- 7
- Start Page
- 999
- End Page
- 1003
- ISSN
- 0253-6269
- Abstract
- A new flavonoid, 7-demethylageconyflavone A (1), and five known compounds, tricin (2), ageconyflavone A (3), corylin (4), nectandrin B (5), and 4-ketopinoresinol (6) were isolated from the aerial parts of Eragrostis ferruginea. Their structures were determined using spectroscopic techniques, including 1D- and 2D-NMR. All compounds were tested for the neuroprotective effects against amyloid beta peptide (A beta) using PC12 cells, a major cause of the pathology of Alzheimer's disease. Tricin (2) was found to have a neuroprotective effect with an ED50 value of 20.3 mu M against A beta-induced toxicity in PC12 cells. Ageconyflavone A (3), nectandrin B (5) and 4-ketopinoresinol (6) demonstrated moderate neuroprotective effects with ED50 values of 58.7, 44.1, and 54.8 mu M, respectively.
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Related Researcher
- Lee, Dong ho
- Department of Plant Biotechnology