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A Three-Dimensional and Sensitive Bioassay Based on Nanostructured Quartz Combined with Viral Nanoparticles
- Authors
- Lee, Jong-Hwan; Kim, Jung Suk; Park, Jin-Seung; Lee, Wonbae; Lee, Kyung Eun; Han, Sung-Sik; Lee, Kyu Back; Lee, Jeewon
- Issue Date
- 23-6월-2010
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- bioassay; nanostructure; quartz; viral nanoparticle
- Citation
- ADVANCED FUNCTIONAL MATERIALS, v.20, no.12, pp.2004 - 2009
- Indexed
- SCIE
SCOPUS
- Journal Title
- ADVANCED FUNCTIONAL MATERIALS
- Volume
- 20
- Number
- 12
- Start Page
- 2004
- End Page
- 2009
- ISSN
- 1616-301X
- Abstract
- An effective mask-free method for fabricating high-aspect-ratio pillarlike nanostructures over a large area of a quartz surface via a simple O(2) and CF(4) two-step reactive ion etching (RIE) procedure is developed. The nanostructured quartz surfaces are successfully combined with the engineered viral particles derived from hepatitis B virus capsid, yielding a novel 3D assay system with attomolar sensitivity, which has great potential for use in sensitive and early detection of various disease
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