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Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells

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dc.contributor.authorHwang, Ji Sang-
dc.contributor.authorLee, Seon A.-
dc.contributor.authorHong, Seong Su-
dc.contributor.authorHan, Xiang Hua-
dc.contributor.authorLee, Chul-
dc.contributor.authorKang, Shin Jung-
dc.contributor.authorLee, Dongho-
dc.contributor.authorKim, Youngsoo-
dc.contributor.authorHong, Jin Tae-
dc.contributor.authorLee, Mi Kyeong-
dc.contributor.authorHwang, Bang Yeon-
dc.date.accessioned2021-09-08T02:18:11Z-
dc.date.available2021-09-08T02:18:11Z-
dc.date.created2021-06-11-
dc.date.issued2010-06-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/116239-
dc.description.abstractBioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC(50) values ranging from 9.6 mu M to 35.7 mu M. (C) 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectSESQUITERPENE GLYCOSIDES-
dc.subjectBIBENZYL DERIVATIVES-
dc.subject2 STILBENOIDS-
dc.subjectIN-VITRO-
dc.subjectPICROTOXANE-
dc.subjectCOPACAMPHANE-
dc.subjectMONILIFORME-
dc.subjectCHRYSANTHUM-
dc.subjectVIVO-
dc.titlePhenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Dongho-
dc.identifier.doi10.1016/j.bmcl.2010.04.054-
dc.identifier.scopusid2-s2.0-77954214887-
dc.identifier.wosid000278208200073-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.12, pp.3785 - 3787-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume20-
dc.citation.number12-
dc.citation.startPage3785-
dc.citation.endPage3787-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusSESQUITERPENE GLYCOSIDES-
dc.subject.keywordPlusBIBENZYL DERIVATIVES-
dc.subject.keywordPlus2 STILBENOIDS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusPICROTOXANE-
dc.subject.keywordPlusCOPACAMPHANE-
dc.subject.keywordPlusMONILIFORME-
dc.subject.keywordPlusCHRYSANTHUM-
dc.subject.keywordPlusVIVO-
dc.subject.keywordAuthorDendrobium nobile-
dc.subject.keywordAuthorOrchidaceae-
dc.subject.keywordAuthorPhenanthrene-
dc.subject.keywordAuthorBibenzyl-
dc.subject.keywordAuthorNitric oxide inhibitor-
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