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Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells
- Authors
- Hwang, Ji Sang; Lee, Seon A.; Hong, Seong Su; Han, Xiang Hua; Lee, Chul; Kang, Shin Jung; Lee, Dongho; Kim, Youngsoo; Hong, Jin Tae; Lee, Mi Kyeong; Hwang, Bang Yeon
- Issue Date
- 15-6월-2010
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Dendrobium nobile; Orchidaceae; Phenanthrene; Bibenzyl; Nitric oxide inhibitor
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.12, pp.3785 - 3787
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 20
- Number
- 12
- Start Page
- 3785
- End Page
- 3787
- ISSN
- 0960-894X
- Abstract
- Bioactivity-guided isolation of the methanol extract of the stems of Dendrobium nobile yielded a new phenanthrene together with nine known phenanthrenes and three known bibenzyls. Their structures were elucidated by analysis of the spectroscopic data including 2D-NMR. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-4, 7-13 inhibited nitric oxide production with the IC(50) values ranging from 9.6 mu M to 35.7 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
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