Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeong-Keun | - |
dc.contributor.author | Kim, Mijin | - |
dc.contributor.author | Cho, Ssang-Goo | - |
dc.contributor.author | Kim, Myung-Kyoo | - |
dc.contributor.author | Kim, Suhng Wook | - |
dc.contributor.author | Lim, Young-Hee | - |
dc.date.accessioned | 2021-09-08T02:34:30Z | - |
dc.date.available | 2021-09-08T02:34:30Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 1367-5435 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116283 | - |
dc.description.abstract | Mulberroside A, a glycosylated stilbene, was isolated and identified from the ethanol extract of the roots of Morus alba. Oxyresveratrol, the aglycone of mulberroside A, was produced by enzymatic hydrolysis of mulberroside A using the commercial enzyme Pectinex(A (R)). Mulberroside A and oxyresveratrol showed inhibitory activity against mushroom tyrosinase with an IC(50) of 53.6 and 0.49 mu M, respectively. The tyrosinase inhibitory activity of oxyresveratrol was thus approximately 110-fold higher than that of mulberroside A. Inhibition kinetics showed mulberroside A to be a competitive inhibitor of mushroom tyrosinase with l-tyrosine and l-DOPA as substrate. Oxyresveratrol showed mixed inhibition and noncompetitive inhibition against l-tyrosine and l-DOPA, respectively, as substrate. The results indicate that the tyrosinase inhibitory activity of mulberroside A was greatly enhanced by the bioconversion process. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | ROOT BARK | - |
dc.subject | POLYPHENOL OXIDASES | - |
dc.subject | POTENT INHIBITOR | - |
dc.subject | OXYRESVERATROL | - |
dc.subject | BIOAVAILABILITY | - |
dc.subject | ANTICANCER | - |
dc.subject | GLYCOSIDES | - |
dc.subject | HESPERIDIN | - |
dc.subject | MECHANISM | - |
dc.subject | STILBENE | - |
dc.title | Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Suhng Wook | - |
dc.contributor.affiliatedAuthor | Lim, Young-Hee | - |
dc.identifier.doi | 10.1007/s10295-010-0722-9 | - |
dc.identifier.scopusid | 2-s2.0-77954690029 | - |
dc.identifier.wosid | 000277789300012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.37, no.6, pp.631 - 637 | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.citation.volume | 37 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 631 | - |
dc.citation.endPage | 637 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | ROOT BARK | - |
dc.subject.keywordPlus | POLYPHENOL OXIDASES | - |
dc.subject.keywordPlus | POTENT INHIBITOR | - |
dc.subject.keywordPlus | OXYRESVERATROL | - |
dc.subject.keywordPlus | BIOAVAILABILITY | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | HESPERIDIN | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | STILBENE | - |
dc.subject.keywordAuthor | Biotransformation | - |
dc.subject.keywordAuthor | Mulberroside A | - |
dc.subject.keywordAuthor | Oxyresveratrol | - |
dc.subject.keywordAuthor | Tyrosinase inhibitor | - |
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