Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition
- Authors
- Kim, Jeong-Keun; Kim, Mijin; Cho, Ssang-Goo; Kim, Myung-Kyoo; Kim, Suhng Wook; Lim, Young-Hee
- Issue Date
- 6월-2010
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Biotransformation; Mulberroside A; Oxyresveratrol; Tyrosinase inhibitor
- Citation
- JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, v.37, no.6, pp.631 - 637
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Volume
- 37
- Number
- 6
- Start Page
- 631
- End Page
- 637
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/116283
- DOI
- 10.1007/s10295-010-0722-9
- ISSN
- 1367-5435
- Abstract
- Mulberroside A, a glycosylated stilbene, was isolated and identified from the ethanol extract of the roots of Morus alba. Oxyresveratrol, the aglycone of mulberroside A, was produced by enzymatic hydrolysis of mulberroside A using the commercial enzyme Pectinex(A (R)). Mulberroside A and oxyresveratrol showed inhibitory activity against mushroom tyrosinase with an IC(50) of 53.6 and 0.49 mu M, respectively. The tyrosinase inhibitory activity of oxyresveratrol was thus approximately 110-fold higher than that of mulberroside A. Inhibition kinetics showed mulberroside A to be a competitive inhibitor of mushroom tyrosinase with l-tyrosine and l-DOPA as substrate. Oxyresveratrol showed mixed inhibition and noncompetitive inhibition against l-tyrosine and l-DOPA, respectively, as substrate. The results indicate that the tyrosinase inhibitory activity of mulberroside A was greatly enhanced by the bioconversion process.
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Collections - College of Health Sciences > School of Health and Environmental Science > 1. Journal Articles
- College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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