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Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol

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dc.contributor.authorShin, Hyun Yong-
dc.contributor.authorLee, Jin Young-
dc.contributor.authorJung, You Ree-
dc.contributor.authorKim, Seung Wook-
dc.date.accessioned2021-09-08T02:49:37Z-
dc.date.available2021-09-08T02:49:37Z-
dc.date.created2021-06-11-
dc.date.issued2010-06-
dc.identifier.issn0960-8524-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/116364-
dc.description.abstractIn this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation. (C) 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherELSEVIER SCI LTD-
dc.subjectTRANSCRIPTION FACTOR CPCR1-
dc.subjectCLAVULANIC ACID PRODUCTION-
dc.subjectCYSTATHIONINE-GAMMA-LYASE-
dc.subjectBETA-LACTAM BIOSYNTHESIS-
dc.subjectSTREPTOMYCES-CLAVULIGERUS-
dc.subjectCARBON SOURCE-
dc.subjectCEFT GENE-
dc.subjectMECB GENE-
dc.subjectOPTIMIZATION-
dc.subjectENHANCEMENT-
dc.titleStimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Seung Wook-
dc.identifier.doi10.1016/j.biortech.2010.01.095-
dc.identifier.scopusid2-s2.0-77649338443-
dc.identifier.wosid000276374500041-
dc.identifier.bibliographicCitationBIORESOURCE TECHNOLOGY, v.101, no.12, pp.4549 - 4553-
dc.relation.isPartOfBIORESOURCE TECHNOLOGY-
dc.citation.titleBIORESOURCE TECHNOLOGY-
dc.citation.volume101-
dc.citation.number12-
dc.citation.startPage4549-
dc.citation.endPage4553-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaAgriculture-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalResearchAreaEnergy & Fuels-
dc.relation.journalWebOfScienceCategoryAgricultural Engineering-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryEnergy & Fuels-
dc.subject.keywordPlusTRANSCRIPTION FACTOR CPCR1-
dc.subject.keywordPlusCLAVULANIC ACID PRODUCTION-
dc.subject.keywordPlusCYSTATHIONINE-GAMMA-LYASE-
dc.subject.keywordPlusBETA-LACTAM BIOSYNTHESIS-
dc.subject.keywordPlusSTREPTOMYCES-CLAVULIGERUS-
dc.subject.keywordPlusCARBON SOURCE-
dc.subject.keywordPlusCEFT GENE-
dc.subject.keywordPlusMECB GENE-
dc.subject.keywordPlusOPTIMIZATION-
dc.subject.keywordPlusENHANCEMENT-
dc.subject.keywordAuthorAcremonium chrysogenum-
dc.subject.keywordAuthorIsopenicillin N synthase-
dc.subject.keywordAuthorTransporter-
dc.subject.keywordAuthorGlycerol-
dc.subject.keywordAuthorMorphological characteristics-
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