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Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol
- Issue Date
- 6월-2010
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Acremonium chrysogenum; Isopenicillin N synthase; Transporter; Glycerol; Morphological characteristics
- Citation
- BIORESOURCE TECHNOLOGY, v.101, no.12, pp.4549 - 4553
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIORESOURCE TECHNOLOGY
- Volume
- 101
- Number
- 12
- Start Page
- 4549
- End Page
- 4553
- ISSN
- 0960-8524
- Abstract
- In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation. (C) 2010 Elsevier Ltd. All rights reserved.
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