Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dong-Uk | - |
dc.contributor.author | Hayles, Jacqueline | - |
dc.contributor.author | Kim, Dongsup | - |
dc.contributor.author | Wood, Valerie | - |
dc.contributor.author | Park, Han-Oh | - |
dc.contributor.author | Won, Misun | - |
dc.contributor.author | Yoo, Hyang-Sook | - |
dc.contributor.author | Duhig, Trevor | - |
dc.contributor.author | Nam, Miyoung | - |
dc.contributor.author | Palmer, Georgia | - |
dc.contributor.author | Han, Sangjo | - |
dc.contributor.author | Jeffery, Linda | - |
dc.contributor.author | Baek, Seung-Tae | - |
dc.contributor.author | Lee, Hyemi | - |
dc.contributor.author | Shim, Young Sam | - |
dc.contributor.author | Lee, Minho | - |
dc.contributor.author | Kim, Lila | - |
dc.contributor.author | Heo, Kyung-Sun | - |
dc.contributor.author | Noh, Eun Joo | - |
dc.contributor.author | Lee, Ah-Reum | - |
dc.contributor.author | Jang, Young-Joo | - |
dc.contributor.author | Chung, Kyung-Sook | - |
dc.contributor.author | Choi, Shin-Jung | - |
dc.contributor.author | Park, Jo-Young | - |
dc.contributor.author | Park, Youngwoo | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Park, Hae-Joon | - |
dc.contributor.author | Kang, Eun-Jung | - |
dc.contributor.author | Kim, Hyong Bai | - |
dc.contributor.author | Kang, Hyun-Sam | - |
dc.contributor.author | Park, Hee-Moon | - |
dc.contributor.author | Kim, Kyunghoon | - |
dc.contributor.author | Song, Kiwon | - |
dc.contributor.author | Bin Song, Kyung | - |
dc.contributor.author | Nurse, Paul | - |
dc.contributor.author | Hoe, Kwang-Lae | - |
dc.date.accessioned | 2021-09-08T02:58:33Z | - |
dc.date.available | 2021-09-08T02:58:33Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 1087-0156 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116410 | - |
dc.description.abstract | We report the construction and analysis of 4,836 heterozygous diploid deletion mutants covering 98.4% of the fission yeast genome providing a tool for studying eukaryotic biology. Comprehensive gene dispensability comparisons with budding yeast-the only other eukaryote for which a comprehensive knockout library exists-revealed that 83% of single-copy orthologs in the two yeasts had conserved dispensability. Gene dispensability differed for certain pathways between the two yeasts, including mitochondrial translation and cell cycle checkpoint control. We show that fission yeast has more essential genes than budding yeast and that essential genes are more likely than nonessential genes to be present in a single copy, to be broadly conserved and to contain introns. Growth fitness analyses determined sets of haploinsufficient and haploproficient genes for fission yeast, and comparisons with budding yeast identified specific ribosomal proteins and RNA polymerase subunits, which may act more generally to regulate eukaryotic cell growth. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | PROTEIN LOCALIZATION | - |
dc.subject | GLOBAL ANALYSIS | - |
dc.subject | SACCHAROMYCES | - |
dc.subject | SCREEN | - |
dc.subject | CONSERVATION | - |
dc.subject | MECHANISMS | - |
dc.subject | MUTATIONS | - |
dc.subject | EFFICIENT | - |
dc.subject | NETWORKS | - |
dc.subject | MODULES | - |
dc.title | Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hwan Mook | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Hyong Bai | - |
dc.identifier.doi | 10.1038/nbt.1628 | - |
dc.identifier.scopusid | 2-s2.0-77953255163 | - |
dc.identifier.wosid | 000278820200027 | - |
dc.identifier.bibliographicCitation | NATURE BIOTECHNOLOGY, v.28, no.6, pp.617 - U111 | - |
dc.relation.isPartOf | NATURE BIOTECHNOLOGY | - |
dc.citation.title | NATURE BIOTECHNOLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 617 | - |
dc.citation.endPage | U111 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | PROTEIN LOCALIZATION | - |
dc.subject.keywordPlus | GLOBAL ANALYSIS | - |
dc.subject.keywordPlus | SACCHAROMYCES | - |
dc.subject.keywordPlus | SCREEN | - |
dc.subject.keywordPlus | CONSERVATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.subject.keywordPlus | NETWORKS | - |
dc.subject.keywordPlus | MODULES | - |
dc.subject.keywordAuthor | schizosaccharomyces pombe | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.