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Rigiflex Lithography-Based Nanodot Arrays for Localized Surface Plasmon Resonance Biosensors

Authors
Park, Dong KyuKim, Hye InKim, Jun PyoPark, Je SeobLee, Su YeonYang, Seung-ManLee, JeewonChung, Chan-HwaSim, Sang JunYoo, Pil J.
Issue Date
4-5월-2010
Publisher
AMER CHEMICAL SOC
Citation
LANGMUIR, v.26, no.9, pp.6119 - 6126
Indexed
SCIE
SCOPUS
Journal Title
LANGMUIR
Volume
26
Number
9
Start Page
6119
End Page
6126
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116455
DOI
10.1021/la100598v
ISSN
0743-7463
Abstract
We present a facile and robust means of fabricating metallic nanodot arrays for localized surface plasmon resonance (LSPR) biosensors through the strategic coupling of a polymeric template prepared with rigiflex lithography and a subsequent metallization via electrodeposition. Rigiflex lithography provides the capability to realize large-scale nanosized features as well as process flexibility during contact molding. In addition, the electrodeposition process enables wet-based nanoscale metallization with high pattern fidelity and geometric controllability. Generated metallic nanodot arrays can be used as a general platform for LSPR biosensors via the sequential binding of chemicals and biomolecules. Extinction spectra of the corresponding LSPR signal are measured with UV-vis-NIR spectroscopy, from which the pattern size and shape dependence of LSPR are readily confirmed. The feasibility of a very sensitive biosensor is demonstrated by the targeted binding of human immunoglobulin G, yielding subnanomolar detection capability with high selectivity.
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공과대학 (화공생명공학과)
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