Effectiveness of Topical Chia Seed Oil on Pruritus of End-stage Renal Disease (ESRD) Patients and Healthy Volunteers
- Authors
- Jeong, Se Kyoo; Park, Hyun Jung; Park, Byeong Deog; Kim, Il-Hwan
- Issue Date
- 5월-2010
- Publisher
- KOREAN DERMATOLOGICAL ASSOC
- Keywords
- Alpha-linolenic acid; Chia seed oil; End-stage renal failure; Omega-3 fatty acids; Pruritus
- Citation
- ANNALS OF DERMATOLOGY, v.22, no.2, pp.143 - 148
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANNALS OF DERMATOLOGY
- Volume
- 22
- Number
- 2
- Start Page
- 143
- End Page
- 148
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/116539
- DOI
- 10.5021/ad.2010.22.2.143
- ISSN
- 1013-9087
- Abstract
- Background: Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% to 80% of patients with end-stage renal disease (ESRD) complain about pruritus and xerosis, there are few reports on the effects of topical n-3 fatty acid on these symptoms. Objective: In order to investigate the possible beneficial effects of topical n-3 fatty acid, oils extracted from chia (Salvia hispanica) seed were formulated into topical products, the effects of which were measured. Methods: Five healthy volunteers having xerotic pruritus symptoms and 5 patients with pruritus caused by either ESRD or diabetes were involved in this study. A topical formulation containing 4% chia seed oils were applied for an 8-week duration. Subjective itching symptoms were assessed on a 6-point scale, as were other skin functions, namely trans-epidermal water loss and skin capacitance. Results: After the 8 weeks of application, significant improvements in skin hydration, lichen simplex chronicus, and prurigo nodularis were observed in all patients. A similar improvement was also observed among healthy volunteers with xerotic pruritus. Improvement of epidermal permeability barrier function and skin hydration, represented by trans-epidermal water loss and skin capacitance, respectively, were also observed. No adverse effects were observed in all the tested patients and volunteers. Conclusion: Chia seed oil can be used as an adjuvant moisturizing agent for pruritic skin, including that of ESRD patients. (Ann Dermatol 22(2) 143 similar to 148, 2010)
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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