microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choe, Junho | - |
dc.contributor.author | Cho, Hana | - |
dc.contributor.author | Lee, Hyung Chul | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-08T03:42:31Z | - |
dc.date.available | 2021-09-08T03:42:31Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116600 | - |
dc.description.abstract | Imperfect base-pairing between microRNA (miRNA) and the 30-untranslated region of target messenger RNA (mRNA) triggers translational repression of the target mRNA. Here, we provide evidence that human Argonaute 2 targets cap-binding protein (CBP) 80/20-bound mRNAs and exon junction complex-bound mRNAs and inhibits nonsense-mediated mRNA decay (NMD), which is restricted tightly to CBP80/20-bound mRNAs. Furthermore, microarray analyses reveal that a subset of cellular transcripts, which are expected to be targeted for NMD, is stabilized by miRNA-mediated gene silencing. The regulation of NMD by miRNAs will shed light on a new post-transcriptional regulation mechanism of gene expression in mammalian cells. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | QUALITY-CONTROL | - |
dc.subject | TRANSLATION | - |
dc.subject | MACHINERY | - |
dc.subject | PATHWAY | - |
dc.title | microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1038/embor.2010.44 | - |
dc.identifier.scopusid | 2-s2.0-77951880949 | - |
dc.identifier.wosid | 000277157900015 | - |
dc.identifier.bibliographicCitation | EMBO REPORTS, v.11, no.5, pp.380 - 386 | - |
dc.relation.isPartOf | EMBO REPORTS | - |
dc.citation.title | EMBO REPORTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 380 | - |
dc.citation.endPage | 386 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | MACHINERY | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | Ago2 | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | CBP80/20 | - |
dc.subject.keywordAuthor | eIF4E | - |
dc.subject.keywordAuthor | NMD | - |
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