microRNA/Argonaute 2 regulates nonsense-mediated messenger RNA decay
- Authors
- Choe, Junho; Cho, Hana; Lee, Hyung Chul; Kim, Yoon Ki
- Issue Date
- 5월-2010
- Publisher
- WILEY
- Keywords
- Ago2; microRNA; CBP80/20; eIF4E; NMD
- Citation
- EMBO REPORTS, v.11, no.5, pp.380 - 386
- Indexed
- SCIE
SCOPUS
- Journal Title
- EMBO REPORTS
- Volume
- 11
- Number
- 5
- Start Page
- 380
- End Page
- 386
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/116600
- DOI
- 10.1038/embor.2010.44
- ISSN
- 1469-221X
- Abstract
- Imperfect base-pairing between microRNA (miRNA) and the 30-untranslated region of target messenger RNA (mRNA) triggers translational repression of the target mRNA. Here, we provide evidence that human Argonaute 2 targets cap-binding protein (CBP) 80/20-bound mRNAs and exon junction complex-bound mRNAs and inhibits nonsense-mediated mRNA decay (NMD), which is restricted tightly to CBP80/20-bound mRNAs. Furthermore, microarray analyses reveal that a subset of cellular transcripts, which are expected to be targeted for NMD, is stabilized by miRNA-mediated gene silencing. The regulation of NMD by miRNAs will shed light on a new post-transcriptional regulation mechanism of gene expression in mammalian cells.
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Collections - Graduate School > Department of Life Sciences > 1. Journal Articles
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