NF-kappa B Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia
DC Field | Value | Language |
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dc.contributor.author | Jang, Pil-Geum | - |
dc.contributor.author | Namkoong, Cherl | - |
dc.contributor.author | Kang, Gil Myoung | - |
dc.contributor.author | Hur, Man-Wook | - |
dc.contributor.author | Kim, Seung-Whan | - |
dc.contributor.author | Kim, Geun Hyang | - |
dc.contributor.author | Kang, Yeoungsup | - |
dc.contributor.author | Jeon, Min-Jae | - |
dc.contributor.author | Kim, Eun Hee | - |
dc.contributor.author | Lee, Myung-Shik | - |
dc.contributor.author | Karin, Michael | - |
dc.contributor.author | Baik, Ja-Hyun | - |
dc.contributor.author | Park, Joong-Yeol | - |
dc.contributor.author | Lee, Ki-Up | - |
dc.contributor.author | Kim, Young-Bum | - |
dc.contributor.author | Kim, Min-Seon | - |
dc.date.accessioned | 2021-09-08T04:27:32Z | - |
dc.date.available | 2021-09-08T04:27:32Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-03-26 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/116783 | - |
dc.description.abstract | Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanisms underlying these phenomena, we established animal models of infection-associated anorexia by administrating bacterial and viral products, lipopolysaccharide (LPS) and human immunodeficiency virus-1 transactivator protein (Tat). In these models, we found that the nuclear factor-kappa B (NF-kappa B), a pivotal transcription factor for inflammation-related proteins, was activated in the hypothalamus. In parallel, administration of LPS and Tat increased hypothalamic pro-inflammatory cytokine production, which was abrogated by inhibition of hypothalamic NF-kappa B. In vitro, NF-kappa B activation directly stimulated the transcriptional activity of proopiomelanocortin (POMC), a precursor of anorexigenic melanocortin, and mediated the stimulatory effects of LPS, Tat, and pro-inflammatory cytokines on POMC transcription, implying the involvement of NF-kappa B in controlling feeding behavior. Consistently, hypothalamic injection of LPS and Tat caused a significant reduction in food intake and body weight, which was prevented by blockade of NF-kappa B and melanocortin. Furthermore, disruption of I kappa B kinase-beta, an upstream kinase of NF-kappa B, in POMC neurons attenuated LPS- and Tat-induced anorexia. These findings suggest that infection-associated anorexia and weight loss are mediated via NF-kappa B activation in hypothalamic POMC neurons. In addition, hypothalamic NF-kappa B was activated by leptin, an important anorexigenic hormone, and mediates leptin-stimulated POMC transcription, indicating that hypothalamic NF-kappa B also serves as a downstream signaling pathway of leptin. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | FOOD-INTAKE | - |
dc.subject | RECEPTOR | - |
dc.subject | ALPHA | - |
dc.subject | CACHEXIA | - |
dc.subject | PROTEIN | - |
dc.subject | LIPOPOLYSACCHARIDE | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | SUPPRESSION | - |
dc.subject | EXPRESSION | - |
dc.subject | CYTOKINES | - |
dc.title | NF-kappa B Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, Ja-Hyun | - |
dc.identifier.doi | 10.1074/jbc.M109.070706 | - |
dc.identifier.scopusid | 2-s2.0-77951210900 | - |
dc.identifier.wosid | 000276165900043 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.285, no.13, pp.9706 - 9715 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 285 | - |
dc.citation.number | 13 | - |
dc.citation.startPage | 9706 | - |
dc.citation.endPage | 9715 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | FOOD-INTAKE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | CACHEXIA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CYTOKINES | - |
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