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NF-kappa B Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia

Authors
Jang, Pil-GeumNamkoong, CherlKang, Gil MyoungHur, Man-WookKim, Seung-WhanKim, Geun HyangKang, YeoungsupJeon, Min-JaeKim, Eun HeeLee, Myung-ShikKarin, MichaelBaik, Ja-HyunPark, Joong-YeolLee, Ki-UpKim, Young-BumKim, Min-Seon
Issue Date
26-3월-2010
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.285, no.13, pp.9706 - 9715
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume
285
Number
13
Start Page
9706
End Page
9715
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116783
DOI
10.1074/jbc.M109.070706
ISSN
0021-9258
Abstract
Anorexia and weight loss are prevalent in infectious diseases. To investigate the molecular mechanisms underlying these phenomena, we established animal models of infection-associated anorexia by administrating bacterial and viral products, lipopolysaccharide (LPS) and human immunodeficiency virus-1 transactivator protein (Tat). In these models, we found that the nuclear factor-kappa B (NF-kappa B), a pivotal transcription factor for inflammation-related proteins, was activated in the hypothalamus. In parallel, administration of LPS and Tat increased hypothalamic pro-inflammatory cytokine production, which was abrogated by inhibition of hypothalamic NF-kappa B. In vitro, NF-kappa B activation directly stimulated the transcriptional activity of proopiomelanocortin (POMC), a precursor of anorexigenic melanocortin, and mediated the stimulatory effects of LPS, Tat, and pro-inflammatory cytokines on POMC transcription, implying the involvement of NF-kappa B in controlling feeding behavior. Consistently, hypothalamic injection of LPS and Tat caused a significant reduction in food intake and body weight, which was prevented by blockade of NF-kappa B and melanocortin. Furthermore, disruption of I kappa B kinase-beta, an upstream kinase of NF-kappa B, in POMC neurons attenuated LPS- and Tat-induced anorexia. These findings suggest that infection-associated anorexia and weight loss are mediated via NF-kappa B activation in hypothalamic POMC neurons. In addition, hypothalamic NF-kappa B was activated by leptin, an important anorexigenic hormone, and mediates leptin-stimulated POMC transcription, indicating that hypothalamic NF-kappa B also serves as a downstream signaling pathway of leptin.
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