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Pathways Contributing to Development of Spontaneous Mammary Tumors in BALB/c-Trp53(+/-) Mice

Authors
Yan, HaohengBlackburn, Anneke C.McLary, S. ChristineTao, LuweiRoberts, Amy L.Xavier, Elizabeth A.Dickinson, Ellen S.Seo, Jae HongArenas, Richard B.Otis, Christopher N.Cao, Qing J.Lawlor, Rebecca G.Osborne, Barbara A.Kittrell, Frances S.Medina, DanielJerry, D. Joseph
Issue Date
Mar-2010
Publisher
ELSEVIER SCIENCE INC
Citation
AMERICAN JOURNAL OF PATHOLOGY, v.176, no.3, pp.1421 - 1432
Indexed
SCIE
SCOPUS
Journal Title
AMERICAN JOURNAL OF PATHOLOGY
Volume
176
Number
3
Start Page
1421
End Page
1432
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/116907
DOI
10.2353/ajpath.2010.090438
ISSN
0002-9440
Abstract
Mutation and loss of function in p53 are common features among human breast cancers. Here we use BALB/c-Trp53(+/-) mice as a model to examine the sequence of events leading to mammary tumors. Mammary gland proliferation rates were similar in both BALB/c-TrP53(+/-) mice and wild-type controls. In addition, sporadic mammary hyperplasias were rare in BALB/c-Trp53(+/-) mice and not detectably different from those of wild-type controls. Among the 28 mammary tumors collected from BALB/c-Trp53(+/-) mice, loss of heterozygosity for Trp53 was detected in more than 90% of invasive mammary tumors. Transplantation of Trp53(+/-) ductal hyperplasias also indicated an association between loss of the wild-type allele of Trp53 and progression to invasive carcinomas. Therefore, loss of P53 function seems to be a rate-limiting step in progression. Moreover, expression of biomarkers; such as estrogen receptor a, progesterone receptor, Her2/Neu, and activated Notchl varied among mammary tumors, suggesting that multiple oncogenic lesions collaborate with loss of p53 function. Expression of biomarkers was retained when tumor fragments were transplanted to syngeneic hosts. Tumors expressing solely luminal or basal keratins were also observed (27 and 11%, respectively), but the largest class of tumors expressed both luminal and basal keratins (62%). Overall, this panel of transplantable tumors provides a resource for detailed evaluation of the cell lineages undergoing transformation and preclinical testing of therapeutic agents targeting a variety of oncogenic pathways including cancer stem cells. (Am J Pathol 2010, 176:1421-1432; DOI: 10.2353/ajpath.2010.090438)
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