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Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
- Authors
- Park, YongKeun; Diez-Silva, Monica; Fu, Dan; Popescu, Gabriel; Choi, Wonshik; Barman, Ishan; Suresh, Subra; Feld, Michael S.
- Issue Date
- 3월-2010
- Publisher
- SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
- Keywords
- red blood cell; plasmodium falciparum; light scattering; malaria; electric field
- Citation
- JOURNAL OF BIOMEDICAL OPTICS, v.15, no.2
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF BIOMEDICAL OPTICS
- Volume
- 15
- Number
- 2
- ISSN
- 1083-3668
- Abstract
- We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering. (C) 2010 society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3369966]
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Collections - College of Science > Department of Physics > 1. Journal Articles
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