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Multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole DNA biosensor for label-free detection of genetically modified organisms by QCM and EIS
- Authors
- Lien, Truong Thi Ngoc; Lam, Tran Dai; An, Vu Thi Hong; Hoang, Tran Vinh; Quang, Duong Tuan; Khieu, Dinh Quang; Tsukahara, Toshifumi; Lee, Young Hoon; Kim, Jong Seung
- Issue Date
- 15-1월-2010
- Publisher
- ELSEVIER
- Keywords
- MWCNTs-doped polypyrrole; Electrochemical DNA biosensor; Quartz crystal microbalance; Electrochemical impedance spectroscopy
- Citation
- TALANTA, v.80, no.3, pp.1164 - 1169
- Indexed
- SCIE
SCOPUS
- Journal Title
- TALANTA
- Volume
- 80
- Number
- 3
- Start Page
- 1164
- End Page
- 1169
- ISSN
- 0039-9140
- Abstract
- In this paper, we describe DNA electrochemical detection for genetically modified organism (GMO) based on multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole (PPy). DNA hybridization is studied by quartz crystal microbalance (QCM) and electrochemical impedance spectroscopy (EIS). An increase in DNA complementary target concentration results in a decrease in the faradic charge transfer resistance (R-ct) and signifying "signal-on" behavior of MWCNTs-PPy-DNA system. QCM and EIS data indicated that the electroanalytical MWCNTs-PPy films were highly sensitive (as low as 4 pM of target can be detected with QCM technique). In principle, this system can be suitable not only for DNA but also for protein biosensor construction. (C) 2009 Elsevier B.V. All rights reserved.
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