Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas Laboratory investigation
DC Field | Value | Language |
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dc.contributor.author | Park, Kyung-Jae | - |
dc.contributor.author | Kang, Shin-Hyuk | - |
dc.contributor.author | Chae, Yang-Seok | - |
dc.contributor.author | Yu, Mi-Ok | - |
dc.contributor.author | Cho, Tai-Hyoung | - |
dc.contributor.author | Suh, Jung-Keun | - |
dc.contributor.author | Lee, Hoon-Kap | - |
dc.contributor.author | Chung, Yong-Gu | - |
dc.date.accessioned | 2021-09-08T05:53:29Z | - |
dc.date.available | 2021-09-08T05:53:29Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117192 | - |
dc.description.abstract | Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas. (DOI: 10.3171/2009.4.JNS09158) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC NEUROLOGICAL SURGEONS | - |
dc.subject | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject | DIABETIC MACULAR EDEMA | - |
dc.subject | RETINAL VEIN OCCLUSION | - |
dc.subject | INTRACRANIAL MENINGIOMAS | - |
dc.subject | RADIOLOGICAL CHARACTERISTICS | - |
dc.subject | GLIOBLASTOMA-MULTIFORME | - |
dc.subject | HISTOLOGICAL FACTORS | - |
dc.subject | BARRIER BREAKDOWN | - |
dc.subject | VITREOUS LEVELS | - |
dc.subject | CELL-GROWTH | - |
dc.title | Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas Laboratory investigation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyung-Jae | - |
dc.contributor.affiliatedAuthor | Kang, Shin-Hyuk | - |
dc.contributor.affiliatedAuthor | Chae, Yang-Seok | - |
dc.identifier.doi | 10.3171/2009.4.JNS09158 | - |
dc.identifier.scopusid | 2-s2.0-75749101068 | - |
dc.identifier.wosid | 000273153400010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSURGERY, v.112, no.1, pp.73 - 80 | - |
dc.relation.isPartOf | JOURNAL OF NEUROSURGERY | - |
dc.citation.title | JOURNAL OF NEUROSURGERY | - |
dc.citation.volume | 112 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 80 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | ENDOTHELIAL-GROWTH-FACTOR | - |
dc.subject.keywordPlus | DIABETIC MACULAR EDEMA | - |
dc.subject.keywordPlus | RETINAL VEIN OCCLUSION | - |
dc.subject.keywordPlus | INTRACRANIAL MENINGIOMAS | - |
dc.subject.keywordPlus | RADIOLOGICAL CHARACTERISTICS | - |
dc.subject.keywordPlus | GLIOBLASTOMA-MULTIFORME | - |
dc.subject.keywordPlus | HISTOLOGICAL FACTORS | - |
dc.subject.keywordPlus | BARRIER BREAKDOWN | - |
dc.subject.keywordPlus | VITREOUS LEVELS | - |
dc.subject.keywordPlus | CELL-GROWTH | - |
dc.subject.keywordAuthor | interleukin-6 | - |
dc.subject.keywordAuthor | meningioma | - |
dc.subject.keywordAuthor | peritumoral brain edema | - |
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