Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas Laboratory investigation
- Authors
- Park, Kyung-Jae; Kang, Shin-Hyuk; Chae, Yang-Seok; Yu, Mi-Ok; Cho, Tai-Hyoung; Suh, Jung-Keun; Lee, Hoon-Kap; Chung, Yong-Gu
- Issue Date
- 1월-2010
- Publisher
- AMER ASSOC NEUROLOGICAL SURGEONS
- Keywords
- interleukin-6; meningioma; peritumoral brain edema
- Citation
- JOURNAL OF NEUROSURGERY, v.112, no.1, pp.73 - 80
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NEUROSURGERY
- Volume
- 112
- Number
- 1
- Start Page
- 73
- End Page
- 80
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/117192
- DOI
- 10.3171/2009.4.JNS09158
- ISSN
- 0022-3085
- Abstract
- Object. Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. Methods. Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. Results. Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). Conclusions. The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas. (DOI: 10.3171/2009.4.JNS09158)
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