Evaluation of the Antibacterial Activity of Rhapontigenin Produced from Rhapontin by Biotransformation Against Propionibacterium acnes
- Authors
- Kim, Jeong-Keun; Kim, Narae; Lim, Young-Hee
- Issue Date
- 1월-2010
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- Rhapontigenin; P. acnes; biotransformation; checkerboard test
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.20, no.1, pp.82 - 87
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 20
- Number
- 1
- Start Page
- 82
- End Page
- 87
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/117204
- DOI
- 10.4014/jmb.0907.07022
- ISSN
- 1017-7825
- Abstract
- Biotransformation is often used to improve chemical activity. We evaluated the antimicrobial activity of rhapontigenin, converted from rhapontin after treatment with Pectinex. Rhapontigenin showed 4-16 times higher antimicrobial activity than rhapontin. The activity was higher against Gram-positive strains than Gram-negative strains. Minimum inhibitory concentrations (MICs) of rhapontigenin, retinol, and five antibiotics were determined by the microbroth dilution method for antibiotic-sensitive and -resistant Propionibacterium acnes. We also investigated the in vitro antibacterial activity of rhapontigenin in combination with antibiotic against antibiotic-resistant P acnes. The antibiotic combination effect against resistant P acnes was studied by the checkerboard method. The combination formulations (rhapontigenin and clindamycin, retinol and clindamycin) showed synergistic effects on the inhibition of the growth of clindamycin-resistant P acnes. It is predictable that the combination of antibiotics with rhapontigenin is helpful to treat acne caused by antibiotic-resistant P acnes. The antibacterial activity of rhapontigenin was enhanced by biotransformation.
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