Cytokine expression in placenta-derived mesenchymal stem cells in patients with pre-eclampsia and normal pregnancies
DC Field | Value | Language |
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dc.contributor.author | Hwang, Jong Ha | - |
dc.contributor.author | Lee, Mi Jung | - |
dc.contributor.author | Seok, Oye Sun | - |
dc.contributor.author | Paek, Yu Chin | - |
dc.contributor.author | Cho, Geum Joon | - |
dc.contributor.author | Seol, Hyun Joo | - |
dc.contributor.author | Lee, Jae Kwan | - |
dc.contributor.author | Oh, Min Jeong | - |
dc.date.accessioned | 2021-09-08T05:57:29Z | - |
dc.date.available | 2021-09-08T05:57:29Z | - |
dc.date.created | 2021-06-11 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/117213 | - |
dc.description.abstract | Objectives: The aim of this study was to investigate the levels of cytokines in placenta-derived mesenchymal stem cells (MSCs) in normal pregnancies and those with pre-eclampsia. Materials and methods: C5a, CD40 Ligand, G-CSF, GM-CSF, GRO alpha, I-309, sICAM-1, IFN-gamma, IL-1 alpha, IL-1 beta, IL-1ra, IL-2, IL-4 IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-16, IL-17, IL-17E, IL-23, IL-27, IL-32 alpha, IP-10, I-TAC, MCP-1, MIF, MIP-1 alpha, MIP-1 beta, Serpin E1, RANTES, SDF-1, TNF alpha, and sTREM-1 were measured in mesenchymal stem cells using the human cytokine array panel A. The soluble intracellular adhesion molecule-1 (sICAM-1), stromal-derived factor-1 (SDF-1) and monocyte chemotactic protein-1 (MCP-1) were measured by real-time PCR and confirmed by Western blot analysis. Results: MSCs derived from the deciduas of normal pregnancies had significantly elevated levels of sICAM (p = 0.000) and SDF-1 (p = 0.011), compared to the pregnancies with pre-eclampsia. The level of MCPA in the decidua-derived MSCs was not significantly different. No significant difference was observed between normal and pre-eclamptic pregnancies for the amnion-derived MSCs. Conclusions: The decreased levels of sICAM and SDF-1 found in the decidua-derived MSCs from pre-eclamptic pregnancies might be associated with some of the immunological alterations in pre-eclampsia. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.subject | CIRCULATING ADHESION MOLECULES | - |
dc.subject | HUMAN BONE-MARROW | - |
dc.subject | PROMOTING MIGRATION | - |
dc.subject | PROGENITOR CELLS | - |
dc.subject | ICAM-1 | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | HEMATOPOIESIS | - |
dc.subject | TRAFFICKING | - |
dc.subject | PROFILE | - |
dc.subject | FETAL | - |
dc.title | Cytokine expression in placenta-derived mesenchymal stem cells in patients with pre-eclampsia and normal pregnancies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hwang, Jong Ha | - |
dc.contributor.affiliatedAuthor | Cho, Geum Joon | - |
dc.contributor.affiliatedAuthor | Lee, Jae Kwan | - |
dc.contributor.affiliatedAuthor | Oh, Min Jeong | - |
dc.identifier.doi | 10.1016/j.cyto.2009.08.013 | - |
dc.identifier.scopusid | 2-s2.0-71649092049 | - |
dc.identifier.wosid | 000273864000014 | - |
dc.identifier.bibliographicCitation | CYTOKINE, v.49, no.1, pp.95 - 101 | - |
dc.relation.isPartOf | CYTOKINE | - |
dc.citation.title | CYTOKINE | - |
dc.citation.volume | 49 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 101 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | CIRCULATING ADHESION MOLECULES | - |
dc.subject.keywordPlus | HUMAN BONE-MARROW | - |
dc.subject.keywordPlus | PROMOTING MIGRATION | - |
dc.subject.keywordPlus | PROGENITOR CELLS | - |
dc.subject.keywordPlus | ICAM-1 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | HEMATOPOIESIS | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordPlus | PROFILE | - |
dc.subject.keywordPlus | FETAL | - |
dc.subject.keywordAuthor | Mesenchymal stem cells | - |
dc.subject.keywordAuthor | Placenta | - |
dc.subject.keywordAuthor | Amnion | - |
dc.subject.keywordAuthor | Decidua | - |
dc.subject.keywordAuthor | Cytokines | - |
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