에토좀 입자크기와 멤브레인 특성 조절을 통한 약물의 경피흡수능 향상Enhanced Transdermal Delivery of Drug Compounds Using Scalable and Deformable Ethosomes
- Other Titles
- Enhanced Transdermal Delivery of Drug Compounds Using Scalable and Deformable Ethosomes
- Authors
- 안은정; 심종원; 김한곤; 박기동; 한성식; 최장원; 김진웅
- Issue Date
- 2010
- Publisher
- 사단법인 대한화장품학회
- Keywords
- ethosomes; particle size; deformability; skin permeation; anti-hair loss ingredient
- Citation
- 대한화장품학회지, v.36, no.2, pp.105 - 113
- Indexed
- KCI
OTHER
- Journal Title
- 대한화장품학회지
- Volume
- 36
- Number
- 2
- Start Page
- 105
- End Page
- 113
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/117545
- ISSN
- 1226-2587
- Abstract
- This study introduces a flexible approach to enhance skin permeation by using ethosomes with deformable lipid membranes as well as controllable sizes. To demonstrate this, a set of ethosomes encapsulating an anti-hair loss ingredient, TriaminodilTM, as a model drug, were fabricated with varying their size, which was achieved by solely applying the different level of mechanical energy, while maintaining their chemical composition. After characterization of the ethosomes with dynamic light scattering, transmission electron microscopy, and deformability measurements, it was found that their membrane deformability depended on the particle size. Moreover, studies on in vitro skin permeation and murine anagen induction allowed us to figure out that the membrane deformability of ethosomes essentially affects delivery efficiency of TriaminodilTM through the skin. It was noticeable in our study that there existed an optimum particle size that can not only maximize the delivery of the drug through the skin, but also increase its actual dermatological activity. These findings offer a useful basis for understanding how ethosomes should be designed to improve delivery efficiency of encapsulated drugs therein in the aspects of changing their length scales and membrane properties.
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Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
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