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골수 줄기세포와 주사형 MPEG-PCL diblock copolymer를 이용한 조직공학적 골재생Bone regeneration with injectable MPEG-PCL diblock copolymer and bone marrow mesenchymal stem cell

Other Titles
Bone regeneration with injectable MPEG-PCL diblock copolymer and bone marrow mesenchymal stem cell
Authors
정유민이태형박정균김원석신주희이의석임재석장현석
Issue Date
2010
Publisher
대한악안면성형재건외과학회
Keywords
Injectable scaffold; MPEG-PCL diblock copolymer; Bone tissue engineering; BMP-2; Osteoblasts
Citation
Maxillofacial Plastic Reconstructive Surgery, v.32, no.1, pp.9 - 15
Journal Title
Maxillofacial Plastic Reconstructive Surgery
Volume
32
Number
1
Start Page
9
End Page
15
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/117649
Abstract
Aim of the study: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model. Materials and methods: New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis. Results: The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer. Conclusion: It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
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의과대학 (의학과)
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