자살: 유전자-환경 상호작용Suicide : Gene-Environment Interaction
- Other Titles
- Suicide : Gene-Environment Interaction
- Authors
- 김용구
- Issue Date
- 2010
- Publisher
- 대한생물정신의학회
- Keywords
- Suicide; Gene; Environment; Serotonin; BDNF
- Citation
- 생물정신의학, v.17, no.2, pp.65 - 69
- Indexed
- KCI
- Journal Title
- 생물정신의학
- Volume
- 17
- Number
- 2
- Start Page
- 65
- End Page
- 69
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/117675
- ISSN
- 1225-8709
- Abstract
- Gene-environment interactions are important in pathogenesis of suicide or suicidal behavior. Twin and adoption studies and family studies show that genetic factors play a critical role in suicide or suicidal behavior. Given the strong association between serotonergic neurotransmission and suicide, recent molecular genetic studies have focused on polymorphisms of serotonin genes, especially on serotonin transporter and tryptophan hydroxylase genes. Some studies have revealed a significant interaction between s allele of the serotonin transporter gene and the risk of suicide attempt associated with childhood trauma. In addition, the polymorphism of Brain-derived neurotrophic factor gene also may influence the effect of childhood trauma in relation to the risk of attempting suicide. Future studies should explore genetic and environmental factors in suicide or suicidal behavior and examine for gene and environment interaction.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.