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용매 증발법에 의한 나노 입자 제조 및 아토바스타틴 칼슘의 효과적인 약물전달체로의 응용Atorvastatin calcium-Loaded Polymeric Nanoparticles by Solvent-Evaporation Process and Their Application as a Drug Delivery System

Other Titles
Atorvastatin calcium-Loaded Polymeric Nanoparticles by Solvent-Evaporation Process and Their Application as a Drug Delivery System
Authors
오근상오상권김동민육순홍
Issue Date
2010
Publisher
한국생체재료학회
Keywords
Atorvastatin calcium; pluroic F-68; nanoparticles; drug delivery system; Atorvastatin calcium; pluroic F-68; nanoparticles; drug delivery system
Citation
생체재료학회지, v.14, no.1, pp.1 - 5
Indexed
KCI
Journal Title
생체재료학회지
Volume
14
Number
1
Start Page
1
End Page
5
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/117962
ISSN
1226-4601
Abstract
Atorvastatin calcium-loaded polymeic nanoparticles were prepared and characterized as a delivery system for hydrophobic drugs. For this purpose, pluronic (poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-68)-based polymeric nanoparticles were prepared by solvent evaporation process. FE-SEM (Field Emission-Scanning Electron Microscopy) was used to observe the morphology of polymeric nanoparticles and electrophoretic light scattering was used to observe the particle size. For the application as an efficient delivery system for atorvastatin calcium, the stability of nanoparticles and release profile was observed in the phosphate buffered solution (pH 7.4).
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