The anti-diabetic effects of Kocat-D1 on streptozotocin-induced diabetic rats
DC Field | Value | Language |
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dc.contributor.author | Won, H.-J. | - |
dc.contributor.author | Lee, H.-S. | - |
dc.contributor.author | Kim, J.-T. | - |
dc.contributor.author | Hong, C.-O. | - |
dc.contributor.author | Koo, Y.-C. | - |
dc.contributor.author | Lee, K.-W. | - |
dc.date.accessioned | 2021-09-08T09:05:52Z | - |
dc.date.available | 2021-09-08T09:05:52Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0367-6293 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/118270 | - |
dc.description.abstract | This study was conducted to investigate the anti-diabetic activity of Kocat-D1, which is widely used in traditional medicine to treat diabetes in Shandong, China. Sprague Dawley rats (8 weeks of age) were separated into 4 groups: a normal control, streptozotocin (STZ)-induced diabetic rat group (DM control), Kocat-D1-1 (diabetic rat treated with 0.25 g/kg/day hot water extract), and Kocat-D1-2 (diabetic rat treated with 1 g/kg/day hot water extract). After eight weeks of treatment, the fasting blood glucose levels of the Kocat-D1-1 (334.3±32.9 mg/dL) and Kocat-D1-2 group (259.5±35.0 mg/dL) were significantly lower when compared to the DM control group (451±42.6 mg/dL). Furthermore, the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), albumin and high-density lipoprotein (HDL) cholesterol in the serum of the Kocat-D1-2 group were significantly normalized when compared to the DM control group. However, significant differences were not observed between the Kocat-D1-1 group and the DM control group. Histochemical staining of the liver of the Kocat-D1-2 group revealed no fat accumulation. The insulin level was significantly upregulated in the Kocat-D1-2 group (0.13±0.02 ng/mL) when compared to the DM control group (0.05±0.04 ng/mL). The relative volume of β-cells in the pancreas of the Kocat-D1-2 group (49.4±4.2%) also increased significantly when compared to the DM control group (12.9±7.9%). These results suggest that Kocat-D1 exerts an anti-hyperglycemic effect through the enhancement of insulin secretion. © The Korean Society of Food Science and Technology. | - |
dc.language | Korean | - |
dc.language.iso | ko | - |
dc.subject | Cucumis sativus | - |
dc.subject | Cucurbitaceae | - |
dc.subject | Rattus | - |
dc.title | The anti-diabetic effects of Kocat-D1 on streptozotocin-induced diabetic rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, K.-W. | - |
dc.identifier.scopusid | 2-s2.0-77957745680 | - |
dc.identifier.bibliographicCitation | Korean Journal of Food Science and Technology, v.42, no.2, pp.204 - 209 | - |
dc.relation.isPartOf | Korean Journal of Food Science and Technology | - |
dc.citation.title | Korean Journal of Food Science and Technology | - |
dc.citation.volume | 42 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 204 | - |
dc.citation.endPage | 209 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | Cucumis sativus | - |
dc.subject.keywordPlus | Cucurbitaceae | - |
dc.subject.keywordPlus | Rattus | - |
dc.subject.keywordAuthor | Anti-hyperglycemia | - |
dc.subject.keywordAuthor | Cucurbitaceae | - |
dc.subject.keywordAuthor | Diabetic rat | - |
dc.subject.keywordAuthor | Insulin | - |
dc.subject.keywordAuthor | Streptozotocin | - |
dc.subject.keywordAuthor | Traditional medicine | - |
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