The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study
- Authors
- Hong, S.G.; Kim, J.H.; Lee, Y.S.; Yoon, E.; Lee, H.J.; Hwang, J.K.; Jung, E.S.; Joo, M.K.; Jung, Y.K.; Yeon, J.E.; Park, J.J.; Kim, J.S.; Bak, Y.T.; Byun, K.S.
- Issue Date
- 2010
- Keywords
- B형간염바이러스; B형간염 표면항원; C형간염바이러스 항체; 췌장암; Hepatitis B virus; HBsAg; Anti-HCV; Pancreatic cancer; Hepatitis B virus; HBsAg; Anti-HCV; Pancreatic cancer
- Citation
- The Korean journal of hepatology, v.16, no.1, pp.49 - 56
- Indexed
- SCOPUS
KCI
- Journal Title
- The Korean journal of hepatology
- Volume
- 16
- Number
- 1
- Start Page
- 49
- End Page
- 56
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/118288
- DOI
- 10.3350/kjhep.2010.16.1.49
- ISSN
- 1738-222X
- Abstract
- BACKGROUND/AIMS: An association between past history of hepatitis B virus (HBV) infection and pancreatic cancer (PC) has recently been reported. We investigated whether HBV and hepatitis C virus (HCV) infections are associated with the development of PC in Korea. METHODS: We retrospectively recruited patients with PC and sex- and, age-matched control patients with stomach cancer (SC) during the previous 5 years. Serum HBsAg and anti-HCV were examined, and data on smoking, alcohol intake, diabetes, and the history of chronic pancreatitis (CP) were collected. RESULTS: A total of 506 PC and 1008 SC were enrolled, with respectively 58.1% and 97.3% of these cases being confirmed histologically. The mean age and sex ratio (male:female) were 63.5 years and 1.5:1 in the PC patients and 63.9 years and 1.5:1 in the SC patients respectively (P>0.05). The odds ratios (95% confidence interval, 95% CI) in univariate analysis were 0.90 (0.52-1.56; P=0.70) for HBsAg, 1.87 (0.87-4.01; P=0.11) for anti-HCV, 2.66 (2.04-3.48; P<0.001) for the presence of diabetes, 2.30 (1.83-2.90; P<0.001) for smoking, 1.14 (0.89-1.46; P=0.31) for alcohol intake, and 4.40 (1.66-11.66; P=0.003) for the history of CP. Independent risk factors for PC were presence of diabetes (OR, 2.67; 95% CI, 2.00-3.56; P<0.001), smoking (OR, 2.49; 95% CI, 1.93-3.21; P<0.001) and history of CP (OR, 4.60; 95% CI, 1.56-13.53; P=0.006). CONCLUSIONS: There was no significant association between seropositivity for HBsAg or anti-HCV and PC. Further studies are warranted to clarify the association between HBV infection and PC in regions where HBV is endemic.
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